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Table 6 Evidence of association between MI risk and current use of NSAIDs

From: Risk of new acute myocardial infarction hospitalization associated with use of oral and parenteral non-steroidal anti-inflammation drugs (NSAIDs): a case-crossover study of Taiwan's National Health Insurance claims database and review of current evidence

Reference

Outcome

ns-NSAIDs

Celecoxib

Naproxen

Diclofenac

Ibuprofen

Indomethacin

Meloxica

Observational studies

 

n*

aOR

95%CI

n*

aOR

95%CI

n*

aOR

95%CI

n*

aOR

95%CI

n*

aOR

95%CI

n*

aOR

95%CI

n*

aOR

95%CI

Case-Crossover

                      

Present study

AMI

3573

1.42

1.3, 1.6

210

1.36

1.0, 2.0

231

1.26

0.9, 1.8

1731

1.29

1.1, 1.5

755

1.45

1.2, 1.8

184

1.22

0.8, 1.8

327

0.97

0.7, 1.3

Gislason 2009 [17]

MI in HF

-

1.56

1.2, 2.1

-

1.31

0.9, 2.0

-

1.31

0.6, 2.7

-

1.64

1.2, 2.3

-

1.47

1.2, 1.9

-

  

-

  

Gislason 2006 [18]

re MI

14

1.07

0.8, 1.5

42

1.36

0.7, 2.5

-

  

61

1.67

1.2, 2.4

136

1.32

0.7, 2.5

-

  

-

  

Case-Control

                      

Garcia Rodriguez 2000 [44]

MI

167

1.45

1.2, 1.8

-

  

-

  

-

  

-

  

-

  

-

  

Schlienger 2002 [43]

AMI

242

1.17

1.0, 1.4

-

  

19

0.68

0.4, 1.1

97

1.38

1.1, 1.8

60

1.17

0.9, 1.6

15

1.03

0.6, 1.9

-

  

Solomon 2002 [42]

AMI

390

0.86

0.6, 1.2

-

  

243

0.84

0.7, 1.0

-

  

285

1.02

0.9, 1.2

-

  

-

  

Watson 2002 [41]

TCEs

-

1.16

0.9, 1.5

-

  

26

0.61

0.4, 0.9

-

1.68

1.3, 2.3

-

1.05

0.6, 1.7

-

  

-

  
 

MI

-

1.47

1.0, 2.2

-

  

-

0.57

0.3, 1.1

-

1.68

1.1, 2.5

-

0.74

0.4, 1.6

-

  

-

  

Garcia Rodriguez 2004 [40]

AMI

580

1.07

1.0, 1.2

-

  

49

0.89

0.6, 1.2

213

1.18

1.0, 1.4

155

1.06

0.9, 1.3

29

0.86

0.6, 1.3

25

0.97

0.6, 1.6

Kimmel 2004 [27]

AMI (no aspirin)

126

0.53

0.4, 0.7

-

  

-

0.48

0.3, 0.8

-

  

-

0.52

0.4, 0.7

-

  

-

  
 

(use aspirin)

74

0.83

0.6, 1.2

-

  

-

  

-

  

-

  

-

  

-

  

Solomon 2004 [39]

AMI

371

0.98

-

425

0.93

0.8, 1.0

63

0.98

-

-

  

49

0.95

-

-

  

-

  

Fischer 2005 [28]

AMI

650

1.07

1.0, 1.2

-

  

63

0.96

0.7, 1.4

260

1.23

1.0, 1.5

176

1.16

0.9, 1.5

36

1.36

0.8, 2.3

-

  

Graham 2005 [38]

AMI, CD

534

1.13

1.0, 1.3

126

0.84

0.7, 1.0

367

1·14

1.0, 1.3

-

  

670

1·06

1.0, 1.2

-

  

-

  

Hippisley-Cox 2005 [37]

AMI

181

1.21

1.0, 1.4

93

1.21

1.0, 1.5

96

1.27

1.0, 1.6

542

1.55

1.4, 1.7

460

1.24

1.1, 1.4

-

  

-

  

Johnsen 2005 [36]

AMI

532

1.68

1.5, 1.9

71

1.25

1.0, 1.6

26

1.50

1.0, 2.3

-

  

-

  

-

  

-

  

Kimmel 2005 [29]

MI

319

0.61

0.5, 0.7

18

0.43

0.2, 0.8

-

  

-

  

-

  

-

  

-

  

Levesque 2005 [35]

AMI

51

1.00

0.7, 1.4

287

0.99

0.9, 1.2

23

1.17

0.8, 1.8

-

  

-

  

-

  

7

1.06

0.5, 2.3

Andersohn 2006 [34]

AMI

354

1.14

1.0, 1.2

111

1.56

1.2, 2.0

59

1.15

0.8, 1.6

393

1.37

1.2, 1.6

201

1.04

0.9, 1.3

-

  

-

  

Hawkey 2006 [33]

MI (cc)

36

1.77

1.0, 3.0

-

  

-

  

-

  

-

  

-

  

-

  
 

(hc)

36

2.61

1.4, 5.0

-

  

-

  

-

  

-

  

-

  

-

  

Helin-Salmivaara 2006 [32]

MI

1985

1.34

1.3, 1.4

124

1.06

0.8, 1.3

300

1.19

1.0, 1.4

388

1.35

1.2, 1.5

768

1.41

1.3, 1.6

108

1.56

1.2, 2.0

149

1.06

1.0, 1.6

Jick 2006 [45]

AMI

-

  

62

1.40

0.9, 2.1

44

1.40

0.8, 2.3

94

1.00

0.8, 1.4

102

1.2

0.9, 1.6

-

  

-

  

Brophy 2007 [46]

AMI

51

1.01

0.7, 1.4

287

1.03

0.9, 1.2

23

1.18

0.8, 1.8

-

  

-

  

-

  

7

0.88

0.4, 1.9

Garcia Rodriguez 2008 [31]

MI

940

1.34

1.2,1.5

81

1.33

1.0, 1.8

54

1.04

0.7, 1. 5

353

1.67

1.4, 1.9

143

1.06

0.9, 1.3

29

1.47

0.9, 2.4

59

1.30

0.9, 1.8

van der Linden 2009 [47]

AMI

269

1.41

1.2, 1.6

18

2.53

1.5, 4.2

-

1.21

0.9, 1.7

108

1.51

1.2, 1.9

68

1.56

1.2, 2.1

-

  

-

  

Mangoni 2010 [30]

AMI+

1803

1.02

1.0, 1.1

-

  

284

0.93~1.31+

608

0.82~1.04+

274

0.92~1.32+

-

  

679

0.81~1.21+

    

Cohort

                      

Ray 2002 [26]

AMI, CD

-

  

74

0.96

0.8, 1.2

245

0.93

0.8, 1.1

-

  

190

0.91

0.8, 1.1

-

  

-

  

Ray 2002 [25]

AMI, CD

841

1.05

1.0, 1.1

-

  

201

0.95

0.8, 1.1

-

  

339

1.15

1.0, 1.3

-

  

-

  

Mamdani 2003 [24]

AMI

134

1.20

0.9, 1.4

75

0.90

0.7, 1.2

15

1.00

0.6, 1.7

-

  

-

  

-

  

-

  

Chan 2006 [23]

CV

288

1.44

1.3, 1.7

-

  

-

  

-

  

-

  

-

  

-

  

Gislason 2006 [18]

re MI

14

1.27

1.1, 1.5

42

1.50

1.1, 2.1

-

  

61

1.54

1.2, 1.9

136

1.25

1.1, 1.5

-

  

-

  

Solomon 2006 [22]

AMI, stroke

292

0.95

0.8, 1.1

1342

0.99

0.9, 1.1

108

0.75

0.6, 0.9

86

1.1

0.9, 1.4

151

0.96

0.8, 1.1

-

  

-

  

Hammad 2008 [21]

AMI

18

1.33

0.8, 2.2

-

  

-

  

-

  

-

  

-

  

-

  

van Staa 2008 [20]

AMI

5690

1.12

1.1, 1.2

-

  

526

1.03

0.9, 1.1

2033

1.21

1.2, 1.3

1913

1.04

1.0, 1.1

309

1.27

1.1, 1.4

137

1.12

0.9, 1.3

Roumie 2009 [19]

CV (no CV history)

-

  

300

1.00

0.9, 1.1

424

1.00

0.9, 1.1

57

1.02

0.8, 1.3

355

1.03

0.9, 1.2

95

1.36

1.1, 1.7

-

  
 

CV (CV history)

-

  

312

0.92

0.8, 1.0

306

0.88

0.8, 1.0

49

1.01

0.8, 1.3

281

1.02

0.9, 1.2

60

0.97

0.8, 1.3

-

  

Gislason 2009 [17]

MI in HF

-

1.32

1.1, 1.5

-

1.38

1.1, 1.7

-

1.52

1.1, 2.1

-

1.36

1.1, 1.6

-

1.33

1.2, 1.5

-

  

-

  
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