Skip to main content

Table 3 Adjusted odds ratio and 95% confidence interval for new AMI hospitalization with NSAIDs stratified by hypertension and use of low dose aspirin

From: Risk of new acute myocardial infarction hospitalization associated with use of oral and parenteral non-steroidal anti-inflammation drugs (NSAIDs): a case-crossover study of Taiwan's National Health Insurance claims database and review of current evidence

 

Hypertension diagnosis

 

Low dose aspirin

 
 

with

without

p value

for interaction

user

non-user

p value for interaction

 

(N = 3,672)

(N = 4,682)

 

(N = 905)

(N = 7,449)

 
 

aOR*

95%CI

aOR*

95%CI

 

aOR*

95%CI

aOR*

95%CI

 

ns-NSAIDs

          

   Oral overall

1.56

1.36 - 1.79

1.32

1.15 - 1.51

0.05

1.48

1.10 - 1.99

1.42

1.28 - 1.57

0.93

   Parenteral overall

3.43

2.30 - 5.13

3.18

2.08 - 4.87

0.95

4.95

1.96 - 12.50

3.24

2.38 - 4.40

0.93

Oral

          

   celecoxib

1.81

1.07 - 3.05

1.10

0.66 - 1.83

0.51

1.66

0.67 - 4.10

1.36

0.91 - 2.02

0.43

   diclofenac

1.33

1.11 - 1.60

1.26

1.04 - 1.52

0.50

1.17

0.77 - 1.76

1.30

1.13 - 1.49

0.68

   naproxen

1.30

0.81 - 2.10

1.17

0.67 - 2.04

0.83

2.66

0.89 - 7.91

1.15

0.78 - 1.69

0.27

   ketorolac

7.64

1.74 - 33.47

0.86

0.36 - 2.09

0.03

1.30

0.21 - 8.02

2.19

1.01 - 4.75

0.57

Parenteral

          

   ketorolac

4.96

2.82 - 8.71

3.71

2.16 - 6.39

0.62

7.47

2.31 - 24.21

4.06

2.69 - 6.13

0.66

   ketoprofen

2.73

1.18 - 6.31

1.92

0.83 - 4.46

0.36

1.20

0.09 - 16.21

2.38

1.31 - 4.35

0.39

   diclofenac

1.08

0.44 - 2.65

3.84

1.09 - 13.52

0.15

2.28

0.22 - 24.06

1.86

0.90 - 3.83

0.91

  1. aOR = adjusted odds ratio; 95%CI = 95% confidence interval; ns-NSAIDs = non-selective NSAIDs
  2. * Conditional logistic regression adjusted for important potential time-varying confounding variables of all discordant use of antihypertensive agents, angiotensin converting enzyme inhibitors or aldosterone receptor blockers, calcium channel blockers, statins, insulin, sulfonylurea, thiazolidinedione, and aspirin between case and control period
Back to article page

BMC Cardiovascular Disorders

ISSN: 1471-2261

Contact us