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Table 1 Blood pressure and heart rate changes induced by atropine ( i.v., 0.03 mg/kg ) between sham-operated and 2K1C rats (n = 6)

From: Downregulation of alpha7 nicotinic acetylcholine receptor in two-kidney one-clip hypertensive rats

   Sham 2K1C
   Pre-atropine Post-atropine Pre-atropine Post-atropine
4 weeks SBP (mmHg) 107± 2.1 108± 2.2 161± 8.5 * 163± 7.8
  DBP(mmHg) 78± 3.8 82± 3.7 102± 3.7 * 105± 3.1
  HR (beat/min) 342± 8.6 405±  6.8 ## 380± 16.4 422±  15.6 #
8 weeks SBP (mmHg) 105± 1.3 109± 1.6 155± 4.3 * 156± 5.5
  DBP(mmHg) 70± 1.9 73± 1.3 105± 6.2 * 107± 6.8
  HR (beat/min) 332± 4.4 395±  5.6 ## 336± 9.3 369±  9.3 #
20 weeks SBP (mmHg) 106± 1.1 108± 1.1 174± 4.2 * 176± 2.8
  DBP(mmHg) 72± 1.0 72± 1.3 109± 2.8 * 110± 2.0
  HR (beat/min) 335± 6.8 388±  8.9 ## 345± 6.2 377±  8.8 #
  1. Values are expressed as mean ± SEM. * P < 0.05 vs aged-matched sham-operated rats (unpaired t test). # P < 0.05, ## P < 0.01 vs Pre-atropine (paired t test). SBP, systolic blood pressure; DBP, diastolic blood pressure; HR, heart rate; 2K1C, two-kidney one-clip.