Choice of generic antihypertensive drugs for the primary prevention of cardiovascular disease - A cost-effectiveness analysis

Wisløff, Torbjørn; Selmer, Randi M; Halvorsen, Sigrun; Fretheim, Atle; Norheim, Ole F; Kristiansen, Ivar Sønbø

doi:10.1186/1471-2261-12-26

Table 1 Risk of secondary events during the first year after a primary event

From: Choice of generic antihypertensive drugs for the primary prevention of cardiovascular disease - A cost-effectiveness analysis

Primary event	Secondary event	Probability of secondary event				Comment
		Value	Low	High	Time
Angina	Cardiovascular death (men)	0.0108	0.0060	0.0156	One year	Daly et.al. (EuroHeart) [11]
Angina	Cardiovascular death (women)	0.0134	0.0071	0.0197	One year	Based on Daly et.al. (EuroHeart) [11]
Angina	AMI (men)	0.0153	0.0096	0.0211	One year	Based on Daly et.al. (EuroHeart) [11]
Angina	AMI (women)	0.0173	0.0101	0.0245	One year	Based on Daly et.al. (EuroHeart) [11]
Angina	Stroke (men)	0.0119	0.0069	0.0170	One year	Based on Daly et.al. (EuroHeart) [11]
Angina	Stroke (women)	0.0110	0.0053	0.0168	One year	Based on Daly et.al. (EuroHeart) [11]
Angina	Heart failure (men)	0.0153	0.0096	0.0211	One year	Based on Daly et.al. (EuroHeart) [11]
Angina	Heart failure (women)	0.0181	0.0108	0.0254	One year	Based on Daly et.al. (EuroHeart) [11]
AMI	Death (30-59 years)	0.04	0.074	0.106	One year	Swedish official data [18]
AMI	Death (60-69 years)	0.09	0.074	0.106	One year	Swedish official data [18]
AMI	Death (70-79 years)	0.20	0.074	0.106	One year	Swedish official data [18]
AMI	Death (80 years or more)	0.38	0.074	0.106	One year	Swedish official data [18]
Non-Stemi	Angina*	0.090	0.074	0.106	One year	ICTUS [19]
Non-Stemi	Heart failure	0.246	0.235	0.256	In-hospital	Fox, GRACE [16]
Non-Stemi	Reinfarction	0.014	0.011	0.017	In-hospital**	Hasdai, EuroHeart 1 [12]
Non-Stemi	Stroke	0.018	0.015	0.020	6 months***	Budaj, GRACE [17]
Non-Stemi	Stroke	0.009	0.007	0.011	In-hospital***	Budaj, GRACE [17]
STEMI	Angina*	0.114	0.083	0.145	One year	Zijlstra 1999 [20]
STEMI	Heart failure	0.288	0.277	0.298	In-hospital	Fox, GRACE [16]
STEMI	Reinfarction	0.027	0.022	0.032	In-hospital**	Hasdai, EuroHeart 1 [12]
STEMI	Stroke	0.021	0.018	0.023	6 months***	Budaj, GRACE [17]
STEMI	Stroke	0.013	0.011	0.015	In-hospital***	Budaj, GRACE [17]
Reinfarction	Stroke	Assumed to be the same as after STEMI/non-STEMI
Reinfarction	Angina*	Assumed to be the same as after STEMI/non-STEMI
Reinfarction	Death*	0.242	0.135	0.349	30 days	Andersen, DANAMI-2 [21]
Reinfarction	Heart failure	Assumed to be the same as after STEMI/non-STEMI
Secondary heart failure	A heart failure llasts for 6-12 months	0.500	0.333	0.750		Expert opinion (SH)
Secondary heart failure	Death	0.290	0.240	0.340	One year	Based on EuroHeart 2 [13]
Primary heart failure	Death (men)	0.173	0.132	0.213	One year	Based on EuroHeart 2 [14]
Primary heart failure	Death (women)	0.163	0.116	0.209	One year	Based on EuroHeart 2 [14]
Stroke	Death	0.338	0.315	0.361	One year	Based on registry data Terent et.al. [22] and Kammersgaard et.al. [23]
Stroke	Moderate sequelae	0.072	0.060	0.084	One year	Based on registry data, Riks-Stroke [24]
Stroke	Severe sequelae	0.169	0.158	0.180	One year	Based on registry data, Riks-Stroke [24]

*Adjusted because data stems from RCTs
** In-hospital probabilities are assumed to be half of one-year-probabilities (1/3 - 1 in sensitivity analyses)
***Here exist both in-hospital and 6 month data (see formula under 2.2)

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ISSN: 1471-2261

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