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Table 2 Results from Cox proportional hazard models for individuals with LAF in the Swedish population (1987–2009): parent-offspring analysis (n=16,160)

From: Family history as a risk factor for recurrent hospitalization for lone atrial fibrillation: a nationwide family study in Sweden

Variable

Model 1.A

Model 1.B

Model 1.C

Model 1.D

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

AF in parent(s) (yes/no)

1.23 (1.17-1.30)

1.22 (1.15-1.28)

  

AF in 1 parent

  

1.16 (1.10-1.23)

 

AF in 2 parents

  

1.65 (1.44-1.90)

 

LAF in parent(s) (yes/no)

   

1.42 (1.23-1.63)

Sex (Reference: females)

 

1.20 (1.13-1.27)

1.20 (1.13-1.27)

1.20 (1.13-1.27)

Age at diagnosis of LAF (yearly increase)

 

1.02 (1.02-1.02)

1.02 (1.02-1.02)

1.02 (1.02-1.02)

Age at diagnosis of AF in parent(s)

 

0.99 (0.99-0.99)

  
 

Model 1.E

Model 1.F

Model 1.G

 
 

HR (95% CI)

HR (95% CI)

HR (95% CI)

 

AF in parent(s)

1.07 (1.00-1.14)

1.22 (1.15-1.31)

1.23 (1.15-1.31)

 

Sex (Reference: females)

1.05 (0.97-1.13)

1.22 (1.14-1.31)

1.22 (1.14-1.31)

 

Age at diagnosis of LAF (yearly increase)

1.00 (1.00-1.01)

1.02 (1.02-1.02)

1.02 (1.02-1.02)

 
  1. Model 1.A: HR of parental history of AF. Model 1B: also included sex, age at diagnosis of LAF (centered at the mean value), and terms for the interaction between parental history of AF and age/sex. The interaction terms were only included in the model if the p-values were <0.05. Model 1C: the variable parental history was categorized as no parental history of AF, one parent with AF and two parents with AF. Model 1D: the association of parental history of LAF with time to first recurrence of AF in proband cases in proband cases was determined. Model 1E: time from first until second recurrence of AF was used to calculate the familial HR. Model 1F: time from diagnosis of LAF until second recurrence of AF was used. Model 1G: time to first recurrence of AF in individuals who did not experience any other CVD outcome during the 10-year follow-up period was used to calculate HR.