Variable | Major underdose (n = 223) | Mild underdose (n = 51) | Recommended dose (n = 34) | Excess dose (n = 4) | PValue |
---|---|---|---|---|---|
Age, y | 62.1 ± 10.7 | 67.0 ± 11.3 | 68.6 ± 12.8 | 77.0 ± 17.5 | <0.001 |
 ≥75 years, n (%) | 24 (10.8) | 19 (37.3) | 19 (55.9) | 3 (75) | <0.001 |
Female, n (%) | 60 (26.9) | 10 (19.6) | 6 (17.6) | 1 (25) | 0.531 |
Weight (kg) | 70.3 ± 9.2 | 58.2 ± 9.1 | 55.8 ± 8.8 | 71.5 ± 9.1 | <0.001 |
BMI | 24.7 ± 2.9 | 21.6 ± 2.6 | 21.0 ± 3.1 | 26.2 ± 3.1 | <0.001 |
Diagnosis, n (%) | Â | Â | Â | Â | 0.167 |
 STEMI | 37 (16.6) | 9 (17.6) | 6 (17.6) | 1 (25) |  |
 UA/NSTEMI | 126 (56.5) | 34 (66.7) | 21 (61.8) | 2 (50) |  |
 Atrial fibrillation | 54 (24.2) | 6 (11.8) | 7 (20.6) | 0 |  |
 DVT | 6 (2.7) | 2 (3.9) | 0 | 1 (25) |  |
Hypertension | 134 (60.1) | 34 (66.7) | 23 (67.6) | 3 (75) | 0.668 |
Diabetes mellitus | 53 (23.8) | 7 (13.7) | 9 (26.5) | 0 | 0.267 |
Severe RI | 0 | 0 | 3 (8.8) | 4 (100) | <0.001 |
Creatinine, mg/dl | 0.8 ± 0.2 | 0.8 ± 0.2 | 1.0 ± 0.3 | 2.5 ± 1.0 | <0.001 |
Creatinine clearance, ml/min | 90.6 ± 26.8 | 69.7 ± 16.4 | 61.3 ±22.6 | 24.9 ± 5.0 | <0.001 |
Administration duration, d | 4.1 ± 2.1 | 3.9 ± 1.8 | 4.0 ± 1.6 | 6.5 ± 5.6 | 0.128 |
Length of hospital stay, d | 8.8 ± 5.7 | 9.4 ± 5.8 | 8.2 ± 4.6 | 14.8 ± 16.8 | 0.179 |
Major adverse vascular events, n (%) | 6 (2.7) | 1 (2.0) | 1 (2.9) | 2 (50) | <0.001 |