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Table 4 Association of six variants on 9p21.3: MI study subpopulation with a positive family history vs. MI study subpopulation with a negative family history

From: Six sequence variants on chromosome 9p21.3 are associated with a positive family history of myocardial infarction: a multicenter registry

Variant

Negative Family History n = 404

Risk Allele Frequency

Positive Family History n = 361

Risk Allele Frequency

P value

OR (95% CI)

rs1333040

        
 

C/C

T/T

T: 0.53

C/C

T/T

T: 0.57

0.102

1.426(0.932-2.180)

 

81

107

 

60

113

   

rs10757274

        
 

A/A

G/G

G: 0.48

A/A

G/G

G: 0.56

0.002

1.940(1.269-2.964)

 

96

83

 

65

109

   

rs2383206

        
 

A/A

G/G

G: 0.51

A/A

G/G

G: 0.57

0.015

1.703(1.108-2.618)

 

81

89

 

62

116

   

rs2383207

        
 

A/A

G/G

G: 0.51

A/A

G/G

G: 0.58

0.016

1.696(1.103-2.608)

 

80

89

 

62

117

   

rs10757278

        
 

A/A

G/G

G: 0.47

A/A

G/G

G: 0.55

0.003

1.923(1.256-2.944)

 

96

79

 

67

106

   

rs1333049

        
 

G/G

C/C

C: 0.48

G/G

C/C

C: 0.55

0.003

1.896(1.241-2.898)

 

98

81

 

67

105

   
  1. Genotype distribution and allelic frequencies of the investigated SNPs on 9p21.3 of the study subpopulation with a positive family history were compared with the study subpopulation with a negative family history. P values and Odds ratios (OR) were calculated for the high-risk homozygous alleles.
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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