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Table 3 Association of six variants on 9p21.3: MI study subpopulation with a positive family history vs. Controls

From: Six sequence variants on chromosome 9p21.3 are associated with a positive family history of myocardial infarction: a multicenter registry

Variant

Controls

 

Risk Allele Frequency

Positive Family History

Risk Allele Frequency

P value

OR (95% CI)

rs1333040

b) n = 3532

       
 

C/C

T/T

T: 0.50

C/C

T/T

T: 0.57

<0.0001

1.892 (1.366-2.619)

 

893

889

 

60

113

   

rs10757274

c) n = 9053

       
 

A/A

G/G

G: 0.45

A/A

G/G

G: 0.56

<0.0001

2.625 (1.922-3.585)

 

2752

1758

 

65

109

   

rs2383206

c) n = 9053

       
 

A/A

G/G

G: 0.47

A/A

G/G

G: 0.57

<0.0001

2.351 (1.719-3.214)

 

2489

1981

 

62

116

   

rs2383207

b) n = 3532

       
 

A/A

G/G

G: 0.46

A/A

G/G

G: 0.58

<0.0001

2.570 (1.864-3.543)

 

1016

746

 

62

117

   

rs10757278

b) n = 718

       
 

A/A

G/G

G: 0.43

A/A

G/G

G: 0.55

<0.0001

2.769 (1.904-4.026)

 

224

128

 

67

106

   

rs1333049

a) n = 999

       
 

G/G

C/C

C: 0.46

G/G

C/C

C: 0.55

<0.0001

2.232 (1.567-3.180)

 

292

205

 

67

105

   
  1. Genotype distribution and allelic frequencies of the investigated SNPs on 9p21.3 of the study subpopulation with a positive family history compared to control of the PopGen cohort (a) [11], the Iceland B collective (b) [4] or the Copenhagen City Heart Study (c) [3]. P values and Odds ratios (OR) were calculated for the high-risk homozygous alleles.