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Table 2 Association of six variants on 9p21.3: MI study population vs. controls

From: Six sequence variants on chromosome 9p21.3 are associated with a positive family history of myocardial infarction: a multicenter registry

Variant

Controls

 

Risk Allele Frequency

MI Cases n = 976

 

Risk Allele Frequency

HW

P value

OR (95% CI)

rs1333040

b) n = 3532

        
 

C/C

T/T

T: 0.50

C/C

T/T

T: 0.56

0,993

<0.0001

1.621 (1.317-2.994)

 

893

889

 

181

292

    

rs10757274

c) n = 9053

        
 

A/A

G/G

G: 0.45

A/A

G/G

G: 0.52

0,075

<0.0001

1.904 (1.570-2.309)

 

2752

1758

 

208

253

    

rs2383206

c) n = 9053

        
 

A/A

G/G

G: 0.47

A/A

G/G

G: 0.55

0,06

<0.0001

1.867 (1.535-2.272)

 

2489

1981

 

183

272

    

rs2383207

b) n = 3532

        
 

A/A

G/G

G: 0.46

A/A

G/G

G: 0.55

0,25

<0.0001

2.039 (1.654-2.514)

 

1016

746

 

183

274

    

rs10757278

b) n = 718

        
 

A/A

G/G

G: 0.43

A/A

G/G

G: 0.52

0,062

<0.0001

1.941 (1.458-2.583)

 

224

128

 

211

243

    

rs1333049

a) n = 999

        
 

G/G

C/C

C: 0.46

G/G

C/C

C: 0.52

0,233

<0.0001

1.653 (1.280-2.135)

 

292

205

 

212

246

    
  1. Genotype distribution and allelic frequencies of the investigated SNPs on 9p21.3 of the overall study cohort were compared with control data of the PopGen cohort (a) [11], the Iceland B collective (b) [4] or the Copenhagen City Heart Study (c) [3]. HW: P value for Hardy-Weinberg equilibrium test. P values and Odds ratios (OR) were calculated for the high-risk homozygous alleles.