C-reactive protein is an independent predictor for carotid artery intima-media thickness progression in asymptomatic younger adults (from the Bogalusa Heart Study)

Toprak, Ahmet; Kandavar, Ramprasad; Toprak, Demet; Chen, Wei; Srinivasan, Sathanur; Xu, Ji Hua; Anwar, Asif; Berenson, Gerald S

doi:10.1186/1471-2261-11-78

Table 1 Baseline and follow-up cardiovascular risk characteristics of study cohort by race and sex

From: C-reactive protein is an independent predictor for carotid artery intima-media thickness progression in asymptomatic younger adults (from the Bogalusa Heart Study)

	White		Black		P value*
Baseline survey (2001-2002)	Men (n = 266)	Women (n = 324)	Men (n = 85)	Women (n = 164)	Race	Sex
Age, years	37.0 ± 4.2^¶	36.7 ± 4.2^¶	36.9 ± 3.8^¶	35.5 ± 4.7^¶	< 0.05^f	NS
BMI, kg/m²	29.2 ± 5.8^¶	28.3 ± 7.2^¶	29.8 ± 7.1	32.9 ± 9.1	< 0.001^f	< 0.01^b
Waist/height	0.56 ± 0.08	0.53 ± 0.1^¶	0.55 ± 0.09	0.59 ± 0.11	< 0.001^f	< 0.05
Systolic blood pressure, mm Hg	118 ± 11	111 ± 11	129 ± 17	120 ± 16	< 0.001	< 0.001
Diastolic blood pressure, mm Hg	80 ± 8	75 ± 8	88 ± 13^‡	80 ± 11	< 0.001	< 0.001
Fasting glucose, mg/dl	88 ± 24^¶	84 ± 20^§	91 ± 33	91 ± 35^§	< 0.05^f	NS
Fasting insulin, μU/ml^†	12.8 ± 8.9	11.3 ± 8.3	12.2 ± 9.0	15.3 ± 12.1	< 0.001^f	< 0.05
LDL cholesterol, mg/dl	130 ± 34^‡	124 ± 33	124 ± 45	118 ± 33	NS	NS
Fasting triglycerides, mg/dl^†	165 ± 129	118 ± 69	147 ± 126	88 ± 37	< 0.001^f	< 0.001
HDL cholesterol, mg/dl	41 ± 12	51 ± 13^‡	50 ± 13	51 ± 13	< 0.001^m	< 0.001^w
Total cholesterol/HDL cholesterol	5.0 ± 1.4	4.0 ± 1.1	4.3 ± 1.6^‡	3.8 ± 1.2	< 0.001^m	< 0.05
High-sensitivity C-reactive protein ≥ 2 mg/l	32.6%	47.3%	47.1%	58.1%	< 0.05	< 0.001^w
Current smoker	34.7%	27.2%	53.6%	32.2%	< 0.01^m	< 0.01^b
Follow-up survey (2003-2005)
Age, years	39.3 ± 4.2^¶	39.1 ± 4.2^¶	39.2 ± 3.8^¶	37.9 ± 4.7^¶	< 0.05^f	NS
BMI, kg/m²	29.8 ± 6.2^¶	28.8 ± 7.6^¶	30.0 ± 7.5	33.6 ± 9.3	< 0.01^f	NS
Waist/height	0.56 ± 0.08	0.54 ± 0.1^¶	0.55 ± 0.1	0.59 ± 0.11	< 0.01^f	NS
Systolic blood pressure, mm Hg	118 ± 12	111 ± 12	128 ± 17	121 ± 17	< 0.01	< 0.01^w
Diastolic blood pressure, mm Hg	80 ± 9	75 ± 8	86 ± 14^‡	81 ± 12	< 0.05	< 0.01^w
Fasting glucose, mg/dl	94 ± 33^¶	86 ± 17^§	94 ± 25	96 ± 40^§	< 0.01^f	< 0.01^w
LDL cholesterol, mg/dl	134 ± 39^‡	125 ± 33	122 ± 40	119 ± 36	NS	NS
Fasting triglycerides, mg/dl^†	174 ± 138	122 ± 69	142 ± 115	93 ± 51	< 0.01^f	< 0.01
HDL cholesterol, mg/dl	42 ± 10	52 ± 13^‡	51 ± 16	52 ± 13	< 0.01^m	< 0.001^w
Total cholesterol/HDL cholesterol	5.0 ± 1.4	3.9 ± 1.1	4.0 ± 1.4^‡	4.2 ± 1.4	< 0.01^m	< 0.001^w
Current smoker	33.0%	28.7%	54.1%	32.1%	< 0.01^m	< 0.01^b

*Analysis of covariance (p value adjusted for age).
NS indicates p > 0.05; ^f, females only; ^m, males only; ^b, blacks only; ^w, whites only.
^† Mean values are presented and their Log transformed values were used to calculate p values.
^‡ p < 0.05 baseline survey vs follow-up survey.
^§ p < 0.01 baseline survey vs follow-up survey.
^¶ p < 0.001 baseline survey vs follow-up survey.

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