Outcome | N trials/N pooled | Relative Risk (95% CI) | I2 | Strength of Evidence* | N trials/ N pooled | Relative Risk (95% CI) | I2 |
---|---|---|---|---|---|---|---|
Intermediate Outcomes | Â | Â | Â | Â | Â | Â | Â |
 | All eligible trials |  | Limited to good quality trials | ||||
Catheter Aspiration | Â | Â | Â | Â | Â | Â | Â |
   ST-segment resolution | 15/15 | 1.51 (1.32 to 1.73) | 64.2% | Moderate | 10/10 | 1.39 (1.21 to 1.61) | 60.4% |
   MBG-3 | 13/13 | 1.61 (1.41 to 1.84) | 55.4% | Moderate | 9/9 | 1.75 (1.44 to 2.14) | 69.2% |
   TIMI-3 | 13/13 | 1.08 (1.04 to 1.12) | 11.5% | Moderate | 10/10 | 1.07 (1.04 to 1.11) | 0% |
   Distal embolization | 10/10 | 0.56 (0.39 to 0.79) | 43.4% | High | 8/8 | 0.48 (0.34 to 0.66) | 33.7% |
   No reflow | 8/8 | 0.52 (0.35 to 0.76) | 15.7% | High | 6/6 | 0.45 (0.27 to 0.75) | 22.3% |
Mechanical Thrombectomy | Â | Â | Â | Â | Â | Â | Â |
   ST-segment resolution | 5/5 | 1.16 (0.99 to 1.36) | 75.1% | Low | 5/5 | 1.16 (0.99 to 1.36) | 75.1% |
   MBG-3 | 4/4 | 1.07 (0.80 to 1.43) | 76.5% | Low | 4/4 | 1.07 (0.80 to 1.43) | 76.5% |
   TIMI-3 | 4/4 | 0.98 (0.92 to 1.04) | 67.5% | Moderate | 4/4 | 0.98 (0.92 to 1.04) | 67.5% |
   Distal embolization | 3/3 | 0.44 (0.17 to 1.12) | 41.6% | Moderate | 3/3 | 0.44 (0.17 to 1.12) | 41.6% |
   No reflow | 3/3 | 0.50 (0.17 to 1.48) | 41.7% | Insufficient | 3/3 | 0.50 (0.17 to 1.48) | 41.7% |
Distal Filter Embolic Protection | Â | Â | Â | Â | Â | Â | Â |
   ST-segment resolution | 5/5 | 1.05 (0.97 to 1.15) | 0% | Moderate | 4/4 | 1.05 (0.96 to 1.14) | 0% |
   MBG-3 | 2/2 | 0.97 (0.81 to 1.15) | NA | Moderate | 2/2 | 0.97 (0.81 to 1.15) | NA |
   TIMI-3 | 5/5 | 1.00 (0.90 to 1.11) | 69.6% | Low | 4/4 | 1.02 (0.90 to 1.15) | 70.2% |
   Distal embolization | 1/0 | 0.63 (0.22 to 1.82)†| NA | Insufficient | 1/0 | 0.63 (0.22 to 1.82)†| NA |
   No reflow | 2/2 | 0.59 (0.14 to 2.51) | NA | Insufficient | 1/0 | 1.00 (0.18 to 5.55)†| NA |
Distal Balloon Embolic Protection | Â | Â | Â | Â | Â | Â | Â |
   ST-segment resolution | 4/4 | 1.08 (0.91 to 1.29) | 41.2% | Moderate | 4/4 | 1.08 (0.91 to 1.29) | 41.2% |
   MBG-3 | 6/6 | 1.39 (1.15 to 1.69) | 43.5% | High | 6/6 | 1.39 (1.15 to 1.69) | 43.5% |
   TIMI-3 | 9/8 | 1.11 (1.03 to 1.19) | 60.4% | Low | 8/7 | 1.09 (1.01 to 1.17) | 59.7% |
   Distal embolization | 4/4 | 1.10 (0.67 to 1.81) | 5.8% | Moderate | 4/4 | 1.10 (0.67 to 1.81) | 5.8% |
   No reflow | 4/4 | 0.51 (0.19 to 1.33) | 0% | Insufficient | 4/4 | 0.51 (0.19 to 1.33) | 0% |
Proximal Balloon Embolic Protection | Â | Â | Â | Â | Â | Â | Â |
   ST-segment resolution | 1/0 | 1.11 (0.97 to 1.28)†| NA | Insufficient | 1/0 | 1.11 (0.97 to 1.28)†| NA |
   MBG-3 | 1/0 | 0.98 (0.88 to 1.10)†| NA | Insufficient | 1/0 | 0.98 (0.88 to 1.10)†| NA |
   TIMI-3 | 1/0 | 1.06 (0.98 to 1.15)†| NA | Insufficient | 1/0 | 1.06 (0.98 to 1.16)†| NA |
   Distal embolization | 1/0 | 0.71 (0.37 to 1.35)†| NA | Insufficient | 1/0 | 0.71 (0.38 to 1.33)†| NA |
   No reflow | 1/0 | ---‡ | ---‡ | Insufficient | 1/0 | ---‡ | ---‡ |
Embolic Protection Devices | Â | Â | Â | Â | Â | Â | Â |
   ST-segment resolution | 10/10 | 1.06 (1.00 to 1.13) | 0% | Low | 10/10 | 1.06 (1.00 to 1.13) | 0% |
   MBG-3 | 9/9 | 1.20 (1.02 to 1.40) | 68.2% | Moderate | 9/9 | 1.20 (1.02 to 1.40) | 68.2% |
   TIMI-3 | 15/14 | 1.06 (1.01 to 1.12) | 58.3% | Low | 15/14 | 1.06 (1.01 to 1.12) | 55.4% |
   Distal embolization | 6/6 | 0.91 (0.64 to 1.30) | 0.2% | Moderate | 6/6 | 0.91 (0.64 to 1.30) | 0.2% |
   No reflow | 6/6 | 0.53 (0.24 to 1.18) | 0% | Insufficient | 5/5 | 0.58 (0.25 to 1.37) | 0% |
Harms | Â | Â | Â | Â | Â | Â | Â |
Catheter Aspiration | Â | Â | Â | Â | Â | Â | Â |
   Coronary dissection | 5/5 | 0.30 (0.12 to 0.75) | 0% | High | 5/5 | 0.30 (0.12 to 0.75) | 0% |
   Coronary perforation | 1/0 | ---‡ | ---‡ | Insufficient | 1/0 | ---‡ | ---‡ |
Mechanical Thrombectomy | Â | Â | Â | Â | Â | Â | Â |
   Coronary dissection | 1/0 | 1.51 (0.57 to 4.01)†| NA | Insufficient | 1/0 | 1.51 (0.57 to 4.01)†| NA |
   Coronary perforation | 2/2 | 1.04 (0.15 to 7.04) | NA | Insufficient | 2/2 | 1.04 (0.15 to 7.04) | NA |
Distal Filter Embolic Protection | Â | Â | Â | Â | Â | Â | Â |
   Coronary dissection | 1/0 | ---‡ | ---‡ | Insufficient | 1/0 | ---‡ | ---‡ |
   Coronary perforation | 1/0 | ---‡ | ---‡ | Insufficient | 1/0 | ---‡ | ---‡ |
Distal Balloon Embolic Protection | Â | Â | Â | Â | Â | Â | Â |
   Coronary dissection | 1/0 | ---‡ | ---‡ | Insufficient | 1/0 | ---‡ | ---‡ |
   Coronary perforation | 1/0 | 5.11 (0.53 to infinity)†| NA | Insufficient | 1/0 | 5.11 (0.53 to infinity) †| NA |
Proximal Balloon Embolic Protection | Â | Â | Â | Â | Â | Â | Â |
   Coronary dissection | 0/0 | --- | --- | Insufficient | 0/0 | --- | --- |
   Coronary perforation | 0/0 | --- | --- | Insufficient | 0/0 | --- | --- |
Embolic Protection Devices | Â | Â | Â | Â | Â | Â | Â |
   Coronary dissection | 2/0 | ---‡ | ---‡ | Insufficient | 2/0 | ---‡ | ---‡ |
   Coronary perforation | 1/0 | 5.11 (0.53 to infinity)†| NA | Insufficient | 1/0 | 5.11 (0.53 to infinity) †| NA |