Table 2 Effect of adjunctive devices on final health outcomes using different follow-up

   Mortality

0.79

0.65 (0.39 to 1.10)

0.81 (0.23 to 2.86)

0.61 (0.35 to 1.07)

0.89 (0.31 to 2.51)

0.62 (0.39 to 0.98)

   Myocardial infarction

0.77

0.55 (0.24 to 1.25)

0.32 (0.03 to 3.06)

0.60 (0.25 to 1.45)

0.70 (0.24 to 1.99)

0.51 (0.26 to 1.00)

   Stroke

0.79

3.18 (0.73 to 13.88)

4.94 (0.52 to infinity)

2.77 (0.51 to 14.98)

---*

---†

Target

revascularization

0.70

0.85 (0.53 to 1.38)

1.35 (0.26 to 6.94)

0.82 (0.50 to 1.35)

0.62 (0.40 to 0.96)

0.87 (0.63 to 1.19)

   MACE

0.79

0.80 (0.57 to 1.12)

0.97 (0.36 to 2.58)

0.79 (0.56 to 1.13)

0.66 (0.47 to 0.94)

0.61 (0.26 to 1.41)

   HRQoL

---

---

---

---

---

---

Mechanical Thrombectomy

   Mortality

1

1.25 (0.47 to 3.32)

1.00 (0.24 to 4.16)‡

1.25 (0.47 to 3.32)

1.35 (0.53 to 3.44)

0.50 (0.21 to 1.17)

   Myocardial infarction

1

0.63 (0.21 to 1.96)

1.00 (0.11 to 9.41)‡

0.63 (0.21 to 1.96)

0.57 (0.17 to 1.92)

0.66 (0.13 to 3.29)

   Stroke

1

1.89 (0.55 to 6.48)

---*

1.89 (0.55 to 6.48)

2.05 (0.27 to 15.78)

1.99 (0.26 to 15.14)

Target

revascularization

1

1.62 (0.21 to 12.55)

---*

1.62 (0.21 to 12.55)

0.55 (0.33 to 0.92)

0.68 (0.41 to 1.13)

   MACE

1

1.28 (0.37 to 4.38)

---†

1.28 (0.37 to 4.38)

0.71 (0.41 to 1.20)

0.66 (0.44 to 0.97)

   HRQoL

---

---

---

---

---

---

Distal Filter Embolic Protection

   Mortality

1

1.02 (0.50 to 2.08)

---†

1.02 (0.50 to 2.08)

1.25 (0.38 to 4.16)‡

0.87 (0.43 to 1.78)‡

   Myocardial infarction

1

0.73 (0.12 to 4.44)

---†

0.73 (0.12 to 4.44)

0.09 (0 to 0.74)*

2.35 (0.61 to 8.90)‡

   Stroke

1

1.51 (0.30 to 7.52)‡

---†

1.51 (0.30 to 7.52)‡

---†

---†

Target

revascularization

1

3.02 (0.61 to 14.84)

---†

3.02 (0.70 to 13.01)‡

1.00 (0.35 to 2.82)‡

1.78 (1.09 to 2.93)‡

   MACE

1

1.29 (0.77 to 2.15)

---†

1.29 (0.77 to 2.15)

1.10 (0.68 to 1.78)

1.48 (1.03 to 2.15)‡

   HRQoL

---

---

---

---

---

---

Distal Balloon Embolic Protection

   Mortality

1

0.64 (0.30 to 1.39)

0.69 (0.24 to 2.03)‡

0.64 (0.30 to 1.39)

0.86 (0.48 to 1.57)

---†

   Myocardial infarction

1

0.85 (0.32 to 2.23)

0.32 (0.00 to 3.71)‡

0.85 (0.32 to 2.23)

0.67 (0.29 to 1.57)

---†

   Stroke

1

0.11 (0 to 0.94)‡

---†

0.11 (0 to 0.94)‡

0.48 (0.10 to 2.22)‡

---†

Target

revascularization

1

1.38 (0.55 to 3.50)

0.32 (0.00 to 3.71)‡

1.38 (0.55 to 3.50)

0.93 (0.61 to 1.42)

---†

   MACE

1

0.74 (0.44 to 1.23)

---*

0.74 (0.44 to 1.23)

0.87 (0.64 to 1.19)

---†

   HRQoL

---

---

---

---

---

---

Proximal Balloon Embolic Protection

   Mortality

1

1.01 (0.14 to 7.10)‡

---†

1.01 (0.18 to 5.69)‡

0.51 (0.11 to 2.33)‡

---†

   Myocardial infarction

1

0.68 (0.11 to 3.99)‡

---†

0.68 (0.14 to 3.34)‡

1.01 (0.24 to 4.33)‡

---†

   Stroke

1

0.34 (0.01 to 8.23)‡

---†

0.34 (0 to 3.87)‡

0.20 (0.00 to 1.93)‡

---†

Target

revascularization

1

0.51 (0.13 to 1.99)‡

---†

0.51 (0.14 to 1.81)‡

0.71 (0.29 to 1.75)‡

---†

   MACE

1

0.61 (0.23 to 1.63)‡

---†

0.61 (0.23 to 1.57)‡

0.74 (0.36 to 1.54)‡

---†

   HRQoL

---

---

---

---

---

---

Embolic Protection Devices

   Mortality

1

0.84 (0.50 to 1.39)

0.69 (0.24 to 2.03)‡

0.84 (0.50 to 1.39)

0.87 (0.52 to 1.46)

0.87 (0.43 to 1.78)‡

   Myocardial infarction

1

0.83 (0.41 to 1.69)

0.32 (0.00 to 3.71)‡

0.83 (0.41 to 1.69)

0.65 (0.31 to 1.33)

2.35 (0.61 to 8.90)‡

   Stroke

1

0.56 (0.11 to 2.84)

---†

0.56 (0.11 to 2.84)

0.39 (0.09 to 1.71)

---†

Target

revascularization

1

1.24 (0.62 to 2.48)

0.32 (0.00 to 3.71)‡

1.24 (0.62 to 2.48)

0.90 (0.63 to 1.30)

1.78 (1.09 to 2.93)‡

   MACE

1

0.92 (0.66 to 1.30)

---*

0.92 (0.66 to 1.30)

0.91 (0.71 to 1.16)

1.48 (1.03 to 2.15)‡

   HRQoL

---

---

---

---

---

---