Role of aldosterone on lung structural remodelling and right ventricular function in congestive heart failure

Table 3 Effect of spironolactone on BW, heart morphometric and respiratory function parameters

	Sham	MI	MI+spironolactone
Body Weight (g)	431 ± 9	417 ± 8	392 ± 6**‡
Scar Weight (g)	N/A	0.14 ± 0.02*	0.12 ± 0.02**
Scar Weight/Body Weight (%)	N/A	0.033 ± 0.005†	0.04 ± 0.01†
Scar Surface (mm²)	N/A	115 ± 9*	111 ± 8*
Scar Weight/Scar Surface (g/mm²)	N/A	0.111 ± 0.008*	0.097 ± 0.008*
Respiratory elastance (cmH₂O/ml)	0.78 ± 0.03	1.2 ± 0.1†	1.2 ± 0.1†
A Parameter, Salazar-Knowles	11.0 ± 0.2	9.6 ± 0.3†	9.3 ± 0.4**
B Parameter, Salazar-Knowles	17.9 ± 0.7	13.8 ± 0.8**	13.5 ± 0.8**
K Parameter, Salazar-Knowles	0.173 ± 0.005	0.148 ± 0.006†	0.145 ± 0.006†

A, estimate of the inspiratory capacity; B, estimate of total lung capacity (p = 0); K, curvature parameter of P-V loop.
*p < 0.0001 vs. Sham; **p < 0.01 vs. Sham; †p < 0.05 vs. Sham; ‡p < 0.05 vs. MI.

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