Genotype-informed estimation of risk of coronary heart disease based on genome-wide association data linked to the electronic medical record

Table 4 Reclassification of 10-y CHD risk after the addition of genotype information (log _e pRR)

10-y CHD risk	FRS	Risk	FRS+log _e pRR
			Low	INT	INT-high	High
Low (≤5%)	196 (15.8%)	pRR	151	45	0	0
		Lower	161	35	0	0
		Upper	148	48	0	0
INT (>5%,≤10%)	392 (31.5%)	pRR	88	240	64	0
		Lower	59	288	45	0
		Upper	112	199	81	0
INT-high (>10%,≤20%)	422 (34.0%)	pRR	1	90	286	45
		Lower	0	67	322	33
		Upper	11	115	241	55
High (>20%)	233 (18.7%)	pRR	0	0	49	184
		Lower	0	0	36	197
		Upper	0	6	53	174
Total	1243	pRR	240 (19.3%)	375 (30.2%)	399 (32.1%)	229 (18.4%)
		Lower	220 (17.7%)	390 (31.4%)	403 (32.4%)	230 (18.5%)
		Upper	271 (21.8%)	368 (29.6%)	375 (30.2%)	229 (18.4%)

INT: Intermediate; pRR, risk relative to the general population from Eq. (6)
Lower and Upper: the lower and upper 95% confidence level for odds ratios used to calculate pRR