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Table 4 Reclassification of 10-y CHD risk after the addition of genotype information (log e pRR)

From: Genotype-informed estimation of risk of coronary heart disease based on genome-wide association data linked to the electronic medical record

10-y CHD risk FRS Risk FRS+log e pRR
    Low INT INT-high High
Low (≤5%) 196 (15.8%) pRR 151 45 0 0
   Lower 161 35 0 0
   Upper 148 48 0 0
INT (>5%,≤10%) 392 (31.5%) pRR 88 240 64 0
   Lower 59 288 45 0
   Upper 112 199 81 0
INT-high (>10%,≤20%) 422 (34.0%) pRR 1 90 286 45
   Lower 0 67 322 33
   Upper 11 115 241 55
High (>20%) 233 (18.7%) pRR 0 0 49 184
   Lower 0 0 36 197
   Upper 0 6 53 174
Total 1243 pRR 240 (19.3%) 375 (30.2%) 399 (32.1%) 229 (18.4%)
   Lower 220 (17.7%) 390 (31.4%) 403 (32.4%) 230 (18.5%)
   Upper 271 (21.8%) 368 (29.6%) 375 (30.2%) 229 (18.4%)
  1. INT: Intermediate; pRR, risk relative to the general population from Eq. (6)
  2. Lower and Upper: the lower and upper 95% confidence level for odds ratios used to calculate pRR