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Table 3 Reclassification of 10-y CHD risk after the addition of genotype information (γ G )

From: Genotype-informed estimation of risk of coronary heart disease based on genome-wide association data linked to the electronic medical record

10-y CHD risk

FRS

Risk

FRS+γ G

   

Low

INT

INT-high

High

Low (≤5%)

196 (15.8%)

ORs

146

50

0

0

  

Lower

156

40

0

0

  

Upper

138

58

0

0

INT (>5%,≤10%)

392 (31.5%)

ORs

76

230

86

0

  

Lower

55

285

52

0

  

Upper

91

200

98

3

INT-high (>10%,≤20%)

422 (34.0%)

ORs

1

77

292

52

  

Lower

0

62

322

38

  

Upper

5

98

239

80

High (>20%)

233 (18.7%)

ORs

0

0

38

195

  

Lower

0

0

29

204

  

Upper

0

2

45

186

Total

1243

ORs

223 (17.9%)

357 (28.7%)

416 (33.5%)

247 (19.9%)

  

Lower

211 (17.0%)

387 (31.3%)

403 (32.4%)

242 (19.5%)

  

Upper

234 (18.8%)

358 (28.8%)

382 (30.7%)

269 (21.6%)

  1. INT: Intermediate; γ G : combined odds ratio from Eq. (3)
  2. Lower and Upper: the lower and upper 95% confidence level for odds ratios used to calculate γ G