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Table 3 Reclassification of 10-y CHD risk after the addition of genotype information (γ G )

From: Genotype-informed estimation of risk of coronary heart disease based on genome-wide association data linked to the electronic medical record

10-y CHD risk FRS Risk FRS+γ G
    Low INT INT-high High
Low (≤5%) 196 (15.8%) ORs 146 50 0 0
   Lower 156 40 0 0
   Upper 138 58 0 0
INT (>5%,≤10%) 392 (31.5%) ORs 76 230 86 0
   Lower 55 285 52 0
   Upper 91 200 98 3
INT-high (>10%,≤20%) 422 (34.0%) ORs 1 77 292 52
   Lower 0 62 322 38
   Upper 5 98 239 80
High (>20%) 233 (18.7%) ORs 0 0 38 195
   Lower 0 0 29 204
   Upper 0 2 45 186
Total 1243 ORs 223 (17.9%) 357 (28.7%) 416 (33.5%) 247 (19.9%)
   Lower 211 (17.0%) 387 (31.3%) 403 (32.4%) 242 (19.5%)
   Upper 234 (18.8%) 358 (28.8%) 382 (30.7%) 269 (21.6%)
  1. INT: Intermediate; γ G : combined odds ratio from Eq. (3)
  2. Lower and Upper: the lower and upper 95% confidence level for odds ratios used to calculate γ G