Table 1 Relative Daily Potency of the HMG-CoA Reductase Inhibitors [Statins] and Non-statin Lipid-lowering Drugs
Drug | Daily dose range in study population | Effect on LDL Cholesterol* [% decrease] | Relative potency†of lowest and highest dose |
|---|---|---|---|
Statins | Â | Â | Â |
Atorvastatin | 5-80 mg | 32-50% | 0.89, 1.39 |
Fluvastatin | 20-80 mg | 22-35% | 0.61, 0.97 |
Lovastatin | 10-120 mg | 21-50% | 0.58, 1.39 |
Pravastatin | 5-320 mg | 15-40% | 0.42, 1.11 |
Rosuvastatin | 2.2-60 mg | 39-60% | 1.08, 1.67 |
Simvastatin | 5-160 mg | 22-50% | 0.61, 1.39 |
Non-Statins | Â | Â | Â |
Cholestyramine | 4-16 g | 4-9% | 0.10, 0.25 |
Colesevelam | 625-3750 mg | 5-10% | 0.14, 0.28 |
Colestipol | 1-10 g | 5-10% | 0.14, 0.28 |
Ezetimibe | 5-30 mg | 10-20% | 0.28, 0.56 |
Fenofibrate | 27-320 mg | 5-10% | 0.14, 0.28 |
Gemfibrazole | 300-1200 mg | 5-10% | 0.14, 0.28 |
Niacin | 250-3000 mg | 4-9% | 0.10, 0.25 |
Omega | 3-12 mg | 4-5% | 0.10, 0.14 |