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Table 2 Prediction of poor outcome with clinical, electrophysiological and biological variables

From: Serum neuron-specific enolase as predictor of outcome in comatose cardiac-arrest survivors: a prospective cohort study

  Patients tested, n Abnormal test result, % (95% CI) False positive rate*, % (95% IC) Positive likelihood ratio (95% IC)
Motor response ≤ 2     
   - 24 h-36 h 97 87% [80% - 93%] 56% [45%- 67% 1.7 [1.2 - 2.5]
   - 72 h 87 70% [61% - 80%] 16% [7% - 25%] 5.8 [2.3 -1 4.1]
No corneal reflexes     
   - 24 h-36 h 95 40% [30% - 50%] 12% [2% - 22%] 4.2 [1.4 - 12.4]
   - 72 h 86 36% [26% - 46%] 0% [0%-14%] 26 [1.7 - 415]
No pupillary reflexes     
   - 24 h-36 h 97 26% [17% - 35%] 4% [4% - 12%] 8.3 [1.2 - 58]
   - 72 h 87 21% [12% - 29%] 0% [0% - 14%] 15 [1 - 244]
Myoclonus     
   - 24 h-36 h 97 27% [18% - 36%] 0% [0% -14%] 19 [1.2 - 299]
   - 72 h 87 23% [14% - 32%] 8% [4% - 20%] 3.6 [114]
Epilepsy     
   - 24 h-36 h 97 7% [7% - 12%] 0% [0% -14%] 5.3 [0.3-90]
   - 72 h 87 7% [2% - 12%] 0% [0% -14%] 5.3 [0.31-91]
- Malignant EEG **     
   - 24-36 h 90 44% [34% - 55%] 4% [2% - 10%] 14 [2.1-97]
   - 72 h 73¶¶ 44% [33% - 55%] 0% [0% -17%] 25 [1.6-394]
Highest measurement of NSE ≥ 47 ng/mL     
  97 58% [48% - 68%] 7% [0,4% - 14%] 4.5 [1.8 -11]
Highest measurement of NSE ≥ 97 ng/mL     
  97 36% [27% - 46%] 0% [0% -13%] 25 [1.6-397]
  1. * Patients with abnormal test results and good outcome/all patients with abnormal test results (1-positive predictive value)
  2. ** included isoelectric and burst-suppression pattern with interburst interval of at least 1s and generalised continuous epileptiform discharges
  3. Forty-four patients were still affected by sedative medication
  4. ¶¶ twenty-one patients were still affected by sedative medication