Racial variation in lipoprotein-associated phospholipase A2in older adults

Table 3 Linear regression models predicting Lp-PLA2 activity (nmol/mL-min)

	Race & Sex (Model1)		Model1 + Biological Covariates		Model 1 + Lifestyle Covariates		Model1 + SNPs*		All Covariates
Variables	β	P-value	β	P-value	β	P-value	β	P-value	β	P-value
Race^†
African-American	-24.7	< 0.0001	-18.5	< 0.0001	-27.0	< 0.0001	-22.8	< 0.0001	-18.0	< 0.0001
Hispanic	-10.1	0.009	-10.6	0.0006	-14.4	0.0006	-10.2	0.009	-13.1	0.0001
Asian	-12.1	0.003	-14.2	< 0.0001	-10.4	0.018	-11.9	0.004	-13.9	0.0001
Female gender^‡	-28.1	< 0.0001	-18.2	< 0.0001	-28.3	< 0.0001	-27.6	< 0.0001	-17.4	< 0.0001
Biological Covariates
Age (years)			1.05	0.0006					1.13	0.0006
Diabetes mellitus			-0.057	0.038					-0.067	0.024
History of hypertension			-2.38	0.23					-3.65	0.094
Systolic blood pressure (mmHg)			-0.0034	0.95					0.0012	0.98
Body mass index (kg/m2)			-0.41	0.29					-0.34	0.39
Waist circumference (cm)			0.041	0.79					-0.0066	0.97
LDL (mg/dL)			0.44	< 0.0001					0.45	< 0.0001
HDL (mg/dL)			-0.69	< 0.0001					-0.72	< 0.0001
ADMA^§ (μmol/L)			23.4	0.0048					23.1	0.012
C-reactive protein (mg/L)			-0.23	0.10					-0.22	0.13
Lifestyle/Demographic Covariates
Current smoking					0.035	0.43			0.025	0.49
Exercise (kCal/kg-day)					0.36	0.30			0.38	0.17
% Calories from saturated fat					1.09	0.038			0.047	0.91
% Calories from carbohydrates					0.31	0.045			-0.055	0.66
Annual income ≥ $50,000					-0.023	0.38			0.011	0.60
College graduate					-0.0095	0.70			0.014	0.48
SNPs
Ala379Val							1.20	0.55	1.45	0.40
Arg92His							-2.06	0.26	-3.75	0.015
Ile198Thr							-6.03	0.056	-4.38	0.11

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