Racial variation in lipoprotein-associated phospholipase A2in older adults

Table 2 Linear regression models predicting Lp-PLA2 mass (ng/mL)

	Race & Sex (Model 1)		Model 1 + Biological Covariates		Model 1 + Lifestyle Covariates		Model 1 + SNPs*		All Covariates
Variables	β	P-value	β	P-value	β	P-value	β	P-value	β	P-value
Race^†
African-American	-55.0	< 0.0001	-50.2	< 0.0001	-57.2	< 0.0001	-49.6	< 0.0001	-47.3	< 0.0001
Hispanic	-26.2	0.0016	-25.8	0.0008	-30.1	0.001	-27.7	0.0008	-30.0	0.0004
Asian	-47.1	< 0.0001	-45.7	< 0.0001	-45.4	< 0.0001	-43.1	< 0.0001	-42.0	< 0.0001
Female gender^‡	-24.2	< 0.0001	-18.5	0.0045	-24.5	< 0.0001	-22.8	< 0.0001	-18.4	0.011
Biological Covariates
Age (years)			2.4	0.0016					2.6	0.0019
Diabetes mellitus			-0.0042	0.95					-0.018	0.81
History of hypertension			-3.0	0.53					-3.76	0.49
Systolic blood pressure (mmHg)			0.16	0.23					0.14	0.33
Body mass index (kg/m2)			-0.46	0.63					-0.063	0.95
Waist circumference (cm)			0.092	0.81					-0.026	0.95
LDL (mg/dL)			0.75	< 0.0001					0.75	< 0.0001
HDL (mg/dL)			-0.26	0.094					-0.27	0.11
ADMA^§ (μmol/L)			38.8	0.06					33.2	0.14
C-reactive protein (mg/L)			1.1	0.0017					1.1	0.002
Lifestyle/Demographic Covariates
Current smoking					0.012	0.90			0.0058	0.95
Exercise (kCal/kg-day)					0.63	0.40			0.76	0.28
% Calories from saturated fat					0.081	0.94			-0.96	0.38
% Calories from carbohydrates					-0.43	0.20			-0.60	0.058
Annual income ≥ $50,000					-0.019	0.74			0.051	0.32
College graduate					-0.091	0.086			-0.071	0.15
SNPs
Ala379Val							2.2	0.60	2.5	0.55
Arg92His							11.8	0.0023	11.6	0.0025
Ile198Thr							-8.8	0.19	-6.1	0.37

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