Table 3 Six-and 12-month outcomes of randomized clinical trials comparing an invasive treatment strategy to a delayed invasive or ischemia-guided approach among STEMI patients treated with fibrinolysis.

PRAGUE[17]

12 Months

Death/Non-Fatal Reinfarction

18/100

30/99

0.59 (0.36, 0.99)

0.04^‡

Death

12/100

18/99

0.66 (0.34, 1.30)

0.22^‡

Non-Fatal Reinfarction

6/100

12/99

0.50 (0.19, 1.27)

0.13^‡

SIAM-3[18]

6 Months^†

CABG

6/82

6/81

0.99 (0.33, 2.94)^‡

0.609

TLR

16/82

19/81

0.83 (0.46, 1.50)^‡

0.336

Ischemic Events

4/82

23/81

0.17 (0.06, 0.47)^‡

0.001

Reinfarction

2/82

2/81

0.99 (0.14, 6.84)^‡

0.685

Death

4/82

9/81

0.44 (0.14, 1.37)^‡

0.119

Death/Reinfarction

6/82

11/81

0.54 (0.21, 1.39)^‡

0.146

Death/Reinfarction/TLR

20/82

29/81

0.68 (0.42, 1.10)^‡

0.078

Death/Reinfarction/TLR/Ischemic Events*

21/82

41/81

0.51 (0.33, 0.78)^‡

0.001

6 Months^††

CABG

12/94

19/103

0.69 (0.36, 1.35)^‡

0.185

TLR

22/94

31/103

0.78 (0.49, 1.24)^‡

0.185

Ischemic Events

7/94

28/103

0.27 (0.13, 0.60)^‡

0.001

Reinfarction

3/94

3/103

1.10 (0.23, 5.30)^‡

0.614

Death

4/94

9/103

0.49 (0.16, 1.53)^‡

0.164

Death/Reinfarction

7/94

12/103

0.64 (0.27, 1.56)^‡

0.225

Death/Reinfarction/TLR

26/94

41/103

0.69 (0.46, 1.04)^‡

0.049

Death/Reinfarction/TLR/Ischemic Events

28/94

55/103

0.56 (0.39, 0.80)^‡

0.001

GRACIA-1[19]

12 Months

Death

9/248

16/251

0.55 (0.22, 1.36)

0.16

Non-Fatal Reinfarction

9/248

15/251

0.60 (0.27, 1.36)

0.22

Death/Non-Fatal Reinfarction

17/248

29/251

0.59 (0.33, 1.05)

0.07

Revascularization

9/248

30/251

0.30 (0.15, 0.62)

0.001

Readmission due to Ischemia

37/248

62/251

0.60 (0.42, 0.87)

0.006

Death/Non-Fatal Reinfarction/Revascularization*

23/248

51/251

0.44 (0.28, 0.70)

0.0008

CAPITAL-AMI[20]

6 Months

Death/Recurrent MI/Recurrent Unstable Ischemia, Stroke*

10/86

20/84

0.48 (0.24, 0.96)

0.04

Death

3/86

3/84

0.95 (0.20, 4.59)

1.00

Reinfarction

5/86

12/84

0.40 (0.15, 1.08)

0.07

Recurrent Unstable Ischemia

7/86

17/84

0.39 (0.17, 0.90)

0.03

Stroke

1/86

1/84

0.95 (0.60, 14.99)

1.00

Death/Reinfarction/Stroke

8/86

15/84

0.51 (0.23, 1.14)

0.12

Leipzig[23]

6 Months

Death

5/82

6/82

0.83 (0.22, 2.99)

0.68^¥

Death/Reinfarction/Stroke/Major Bleeding

12/82

21/82

0.57 (0.28, 1.13)

0.10^¥

TRANSFER AMI[27]

6 Months

Death

30/528

23/511

1.27 (0.77, 2.23)

0.39

Reinfarction

21/528

33/511

0.60 (0.34, 1.05)

0.07

Death/Reinfarction

47/528

54/511

0.83 (0.55, 1.25)

0.36

NORDISTEMI[28]

12 Months

Death/Reinfarction/Stroke/New Ischemia*

28/134

36/132

0.77 (0.50, 1.18)^‡

0.22^‡

Death/Reinfarction/Stroke

8/134

21/132

0.38 (0.17, 0.82)^‡

0.008^‡

Death

3/134

4/132

0.74 (0.17, 3.24)^‡

0.72^‡

Reinfarction

4/134

12/132

0.33 (0.11, 0.99)^‡

0.04^‡

Stroke

3/134

7/132

0.42 (0.11, 1.60)^‡

0.22^‡

Recurrent Ischemia

20/134

20/132

0.99 (0.56, 1.74)^‡

0.96^‡