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Table 1 Summary of included study characteristics

From: A systematic review of the clinical effectiveness of 64-slice or higher computed tomography angiography as an alternative to invasive coronary angiography in the investigation of suspected coronary artery disease

Author (Year) Type of scanner Participants analysed (n) Mean age (years) Gender (M/F) Prevalence of CAD (%) Mean heart rate (± SD) (bpm) Level of analysis presented in publication
  Patient Vessel Segment
Level II diagnostic studies
Brodoefel et al (2008) [8] Somatom Sensation 64, Siemens, Germany 102 62.0 82/20 62.7 68.2 ± 13.3 No No Yes
Cademartiri et al (2008a) [13] Somatom Sensation 64, Siemens, Germany 170 57.5 a 124/46 NR 62.7 ± 10.5 No No Yes
Ghostine et al (2008) [14] Somatom Sensation 64, Siemens, Germany 93 65.0 61/32 46.0 73.0 ± 14.0 Yes No Yes
Husmann et al (2008) [15] Somatom Sensation 64, Siemens, Germany 88 64.3 48/40 48.9 63.0 ± 9.2 Yes Yes Yes
Leber et al (2007) [16] Somatom Sensation 64, Siemens, Germany 90 58.0 57/33 47.7 73.0 ± NR Yes No Yes
Leschka et al (2008a) [17] Somatom Sensation 64, Siemens, Germany 74 61.7 50/24 47.3 67.7 ± 13.3 Yes Yes Yes
Leschka et al (2008b) [18] Somatom Sensation 64, Siemens, Germany 114 62.2 73/41 62.3 68.0 ± 13.0 Yes No Yes
Rixe et al (2009) [19] Somatom Sensation 64, Siemens, Germany 76 65.5 47/29 52.6 68.0 ± 9.0 Yes Yes Yes
Shabestari et al (2007) [20] Somatom Sensation 64, Siemens, Germany 138 63.0 103/35 78.3 65.0 ± NR b Yes Yes Yes
Level III-1 diagnostic studies
Achenbach et al (2008) [21] Somatom Sensation 64, Siemens Germany 200 63.0 114/86 44.5 76 ± 13 Yes Yes Yes
Budoff et al (2008) [22] Lightspeed VCT Scanner, GE Healthcare 230 57.0 136/94 24.8 60 ± 12 Yes Yes No
Cademartiri et al (2007) [23] Somatom Sensation 64, Siemens, Germany 72 53.9 38/34 28.0 70.0 ± 9.9 Yes Yes Yes
Hausleiter et al (2007) [24] Somatom Sensation 64 Cardiac, Siemens, Germany 243 62.0 158 c/85 42.0 56.6 ± 6.5 Yes Yes Yes
Herzog et al (2007) [25] Somatom Sensation 64, Siemens, Germany 55 67.0 29/26 34.5 64.0 ± NR Yes Yes Yes
Meijboom et al (2007a) [26] Somatom Sensation 64, Siemens, Germany 104 58.7 a 75/29 85.0 66.0 ± 9.0 Yes Yes Yes
Meijboom et al (2007b) [27] Somatom Sensation 64; Siemens, Germany 402 59.2 a 279/123 62.9 59.5 a ± NR Yes Yes Yes
Meijboom et al (2007c) [28] Somatom Sensation 64, Siemens, Germany 254 59.0 a 171/83 49.6 59.3 a ± NR Yes Yes Yes
Meijboom et al (2008) [12] Somatom Sensation 64, Siemens, Germany; Brilliance 64, Philips, The Netherlands; Toshiba Multi-Slice Aquilion 64, Toshiba, Japan 360 60.0 245/115 68.0 59 ± 9 Yes Yes Yes
Oncel et al (2007) [29] Somatom Sensation 64, Siemens, Germany 80 56.0 61/19 77.5 58.0 ± 10.0 Yes No Yes
Piers et al (2008) [30] Somatom Sensation 64, Siemens, Germany 60 64.0 51/9 63.3 63.0 ± 12.0 Yes Yes Yes
Scheffel et al (2008) [31] Somatom Sensation 64, Siemens, Germany 120 68.2 71/49 55.0 59.0 ± 6.0 Yes Yes Yes
Schlosser et al (2007) [32] Somatom Sensation 64, Siemens, Germany 61 62.4 41/20 NR 57.0 ± 4.0 No Yes Yes
Sheth et al (2008) [33] Toshiba Aquilion 64-detector scanner, Toshiba, Japan 80 56.0 43/37 39.5 NR Yes Yes Yes
Weustink et al (2007) [34] DSCT Somatom Sensation 64, Siemens, Germany. 100 61.0 79/21 77.0 68.0 ± 11.0 Yes Yes Yes
Level III-2 diagnostic studies
Cademartiri et al (2008b) [35] Somatom Sensation 64 Cardiac; Siemens, Germany 134 63.4 98/36 62.7 57.5 a ± NR Yes Yes Yes
Han et al (2008) [36] 64-slice VCT; GE Healthcare 53 59.6 228 d/175 81.1 NR No No Yes
Pugliese et al (2008) [37] Somatom Sensation 64, Siemens, Germany 51 59.0 39/12 74.5 58.0 ± 7.0 Yes No Yes
Yoshida et al (2009) [38] Somatom Sensation 64, Siemens, Germany 70 64.0 50/20 NR 65.0 ± 11.0 No No Yes
  1. Bpm, beats-per-minute; CAD, coronary artery disease; F, female; M, male; NR, not reported.
  2. Levels of evidence were defined according to the NHMRC diagnostic levels of evidence (11)
  3. a Calculated post hoc using a crude weighted average of the two reported sub-groups
  4. b Median heart rate
  5. c There was a discrepancy between the number stated in Table 1 of the publication and the number stated in the text (228 and 226, respectively).
  6. d For all enrolled patients in study