Circulating Angiopoietins-1 and -2, Angiopoietin Receptor Tie-2 and Vascular Endothelial Growth Factor-A as Biomarkers of Acute Myocardial Infarction: a Prospective Nested Case-Control Study

Table 3 Independent predictors of angiogenic factors.

Angiogenic Factor	β	SE	p	Model R²
VEGF-A (pg/mL)*
Log CRP/SD	39.4	6.0	< 0.0001	0.040
Hypertension	30.3	13.1	< 0.0001	0.046
High school graduate or less	-30.3	14.8	0.04	0.051
Current smoking	39.8	15.1	0.008	0.057
Log triglycerides/SD	12.6	6.0	0.03	0.059
Ang-2 (ng/mL)*
Log CRP/SD	0.061	0.016	< 0.0001	0.06
Diabetes	0.244	0.043	< 0.0001	0.09
Current smoking	0.278	0.038	< 0.0001	0.12
Male gender	-0.17	0.034	< 0.0001	0.13
BMI/SD	0.071	0.016	< 0.0001	0.15
Age/10 years	0.069	0.015	< 0.0001	0.16
Alcohol consumption ≥ 3 drinks/day	0.222	0.059	0.0002	0.17
Ang-1 (ng/mL)†
Log CRP/SD	1.16	0.37	0.002	0.02
LDL/SD	1.01	0.38	0.008	0.03
Male gender	-2.14	0.83	0.009	0.04
Occasional alcohol consumption	-2.85	0.89	0.001	0.06
Tie-2 (ng/mL)†
Diabetes	1.91	0.32	< 0.0001	0.07
HDL/SD	-0.48	0.12	< 0.0001	0.10
Log CRP/SD	0.36	0.11	< 0.0001	0.11
Log triglycerides/SD	0.25	0.13	0.05	0.12

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