Intimal Hyperplasia in Balloon Dilated Coronary Arteries is Reduced by Local Delivery of the NO Donor, SIN-1 Via a cGMP-Dependent Pathway

Table 2 Histo-pathological characteristics of PTCA injured coronary arteries 8 weeks after treatment with ODQ + SIN-1 and SIN-1 and control

8 weeks after treatment	ODQ+ SIN-1 n = 11	SIN-1 n = 11	NaCl Controls n = 5	P -value
EEL area (mm²)	2.79 ± 0.55	2.64 ± 1.11	3.28 ± 1,16	ns
Medial area(M) (mm²)	1.16 ± 0.36	1.27 ± 0.46	1.27 ± 0.47	ns
Intimal area (I) (mm²)	0.50 ± 0.59	0.11 ± 0.10	0.73 ± 0.69	< 0.01
Luminal area (L) (mm²)	1.12 ± 0.36	1.26 ± 0.67	1.28 ± 0.91	ns
IEL length (mm)	3.91 ± 1.06	4.40 ± 0.73	4.20 ± 1.37	ns
Fracture length (F) (mm)	0.71 ± 0.54	0.91 ± 0.73	1.21 ± 0.77	ns
Injury index¹	0.22 ± 0.21	0.21 ± 0.19	0.35 ± 0.29	ns
Residual lumen²	0.73 ± 0.26	0.92 ± 0.08	0.63 ± 0.30	< 0.01
Restenosis index³	2.10 ± 2.24	0.60 ± 0.65	1.02 ± 0.70	< 0.01
Intimal hyperplasia⁴	0.25 ± 0.23	0.07 ± 0.06	0.32 ± 0.24	< 0.01

Results are presented as mean ± SD. One-way ANOVA was used for statistical evaluation. EEL: External elastic lamina. IEL: Internal elastic lamina.
¹Injury index: IEL fracture length/IEL circumference.
²Residual lumen: L/(L+I)
³Restenosis index: (I/I+M)/(F/IEL)
⁴Intimal hyperplasia: I/(I+M)
Legend to table 2: PTCA followed by SIN-1 treatment demonstrated significant larger residual lumen and reduced intimal area, restenosis index, and intimal hyperplasia compared to NaCl treated or if treated with ODQ prior to SIN-1. Data presented as mean ± SD. One way ANOVA test.

ISSN: 1471-2261