GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease

Table 4 Localization of Associations by Haplotype Analyses

Gene	rs ID	P_PERMUTE	Haplotypes	Frequency
AGTR1	rs903051	0.0157	AA	0.616
	rs17762633		GA	0.257
			GC	0.127
DEGS2	rs2895845	0.0003	GC	0.688
	rs7157599		GT	0.312
ESR1	rs3003922	0.0004	GTGTAGG	0.638
	rs7748205		GCATGGG	0.130
	rs3020396		CTACGGG	0.068
	rs3003924		CTACGTA	0.068
	rs1884051		CTACGTG	0.040
	rs2982694		*CTGTATG*	0.020
	rs3020327
GRIA1	rs7714428	0.0428	ACT	0.338
	rs12189362		CCT	0.300
	rs10041275		CCC	0.241
	rs17115017		CTT	0.105
	rs17115018		*CTC*	0.011
KCTD1	rs10853666	0.0765	CG	0.582
	rs16942421		TG	0.337
			TT	0.068
			CT	0.013
ZNF385B	rs9973399	0.0012	*CCT*	0.516
	rs6744352		CCG	0.295
	rs2271759		CAT	0.119
	rs6708300		AAT	0.053
	rs10183243		ACT	0.015
	rs16866933	0.0002	A	0.085

Haplotypes rendered in bold and italics differ significantly between cases and controls (p < 0.05). The size of the window is indicated by the number of markers listed for a given block. Haplotype analysis for ACYP2, AP1G2, CACNA1C, NOS3, and NOS1AP failed to improve on the initial association signal. Haplotype analysis was not performed for CSMD2. For ZNF385B, two regions were identified. Abbreviations: Frequency, the frequency of each haplotype; P _PERMUTE, p-value for the gene-wise sliding window.

ISSN: 1471-2261