GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease

Table 2 SNPs meeting genome-wide significance threshold after correction for population stratification, age, and sex

Gene	rsID	P_PCA	P_UNADJ	OR_PCA-ADJ (95% CI)	P_PCA-ADJ	MAF	Call Rate	P_HWE	Region	Position
ACYP2	rs1559040	1.04E-09	2.11E-06	1.54(1.320,1.787)	3.76e-08	0.111	0.990	1.000000	2p16.2	54201254
ZNF385B	rs16866933	1.45E-15	1.54E-10	1.69(1.475,1.925)	6.15e-14	0.085	0.977	0.059204	2q31.2	180274923
	rs4621553	2.18E-08	5.49E-06	1.40(1.243,1.578)	4.12e-08	0.220	0.995	0.001665	5q22.2	113058063
GRIA1	rs12189362	2.23E-12	9.94E-09	1.50(1.322,1.693)	3.22e-10	0.117	0.977	0.242562	5q33.2	153037741
ESR1	rs2982694	3.91E-12	2.62E-08	1.43(1.277,1.596)	6.96e-10	0.138	0.975	0.160104	6q25.1	152327380
	rs10765792	5.69E-15	4.89E-10	1.54(1.369,1.724)	8.47e-13	0.111	0.980	0.031706	11q21	95506348
	rs7307780	2.27E-16	3.11E-12	1.45(1.327,1.592)	5.03e-15	0.186	0.960	0.141220	12q21.2	74506885
	rs12429889	8.93E-23	7.08E-16	1.64(1.479,1.812)	5.28e-20	0.161	0.954	1.000000	13q22.1	73640323
AP1G2	rs2281680	5.45E-06	1.54E-04	1.38(1.227,1.542)	6.05e-08	0.212	0.982	0.260456	14q11.2	23102910
	rs11624056	8.59E-10	1.20E-06	1.43(1.260,1.615)	3.00e-08	0.110	0.967	0.028261	14q31.3	86576001
DEGS2*	rs7157599	9.14E-09	6.98E-11	1.13(1.082,1.185)	1.30e-07	0.312	0.952	0.830456	14q32.2	99695655
	rs17718586	1.70E-08	7.26E-06	1.53(1.324,1.775)	1.70e-08	0.101	0.964	0.424883	17q24.3	66155784
	rs597503	1.49E-11	1.33E-07	1.45(1.273,1.646)	2.34e-08	0.127	0.959	0.668482	18p11.31	6929947
KCTD1	rs16942421	9.11E-11	3.33E-07	1.68(1.429,1.981)	7.75e-10	0.081	0.975	0.742069	18q11.2	22410423

Unless otherwise indicated, a recessive genetic model fit the data best.
* A dominant genetic model fit the data best.
Abbreviations: rsID, Reference Sequence IDentifier for a given single nucleotide polymorphism (SNP); P _PCA, p-value for the PCA-corrected test statistic (i.e., Trend Test for the Additive model, Fisher's Exact Test for Dominant and Recessive Models); P _UNADJ, p-value for the unadjusted test statistic (i.e., Correlation); OR _PCA-ADJ (95% CI), the odds ratio and 95% confidence interval for the test statistic; P _PCA-ADJ, p-value for the test statistic adjusted for PCA, age, and sex; MAF, minor allele frequency; P _HWE, p-value for the Hardy-Weinberg test statistic; Region; chromosomal position for the variation; Position, nucleotide position for the variation.

ISSN: 1471-2261