Table 5 Non-parametric comparisons of cardiac parameters after 2 weeks of exposure to isoproterenol and treatment with P188 in BL10 and mdx mice.
Measurement | Group | N | Median | Range | Overall p-value | Significantly different groups |
|---|---|---|---|---|---|---|
Heart rate (bpm) | BL10 - Untx | 3 | 451 | 410 - 466 | ||
BL10 - Iso | 7 | 645 | 593 - 691 | BL10-Iso vs. MDX-Untx (p = 0.0267) | ||
MDX - Untx | 6 | 454 | 416 - 477 | 0.0001 | MDX-Untx vs. MDX-Iso (p = 0.0325) | |
MDX - Iso | 10 | 593 | 462 - 632 | MDX-Untx vs. MDX-Iso+P188 (p = 0.0129) | ||
MDX - Iso + P188 | 9 | 667 | 632 - 686 | MDX-Iso vs. MDX-Iso+P188 (p = 0.0008) | ||
EF% | BL10 - Untx | 3 | 60.35 | 59.17 - 61.32 | ||
BL10 - Iso | 7 | 80.03 | 77.40 - 86.59 | BL10-Iso vs. MDX-Untx (p = 0.0267) | ||
MDX - Untx | 6 | 59.00 | 50.93 - 62.22 | 0.0001 | BL10-Iso vs. MDX-Iso (p = 0.0060) | |
MDX - Iso | 10 | 65.00 | 50.15 - 75.10 | MDX-Untx vs. MDX-Iso+P188 (p = 0.0149) | ||
MDX - Iso + P188 | 9 | 74.85 | 69.98 - 81.18 | |||
Diastolic BP (mmHg) | BL10 - Untx | 3 | 74 | 57 - 86 | ||
BL10 - Iso | 7 | 95 | 83 - 102 | |||
MDX - Untx | 3 | 58 | 39 - 62 | 0.0026 | BL10-Iso vs. MDX-Iso (p = 0.0441) BL10-Iso vs. MDX-Iso+P188 (p = 0.0267) | |
MDX - Iso | 5 | 56 | 50 - 66 | |||
MDX - Iso + P188 | 6 | 53 | 44 - 60 | |||
Mean BP (mmHg) | BL10 - Untx | 3 | 78 | 67 - 89 | ||
BL10 - Iso | 7 | 97 | 89 - 106 | |||
MDX - Untx | 3 | 67 | 56 - 71 | 0.0031 | BL10-Iso vs. MDX-Iso (p = 0.0431) BL10-Iso vs. MDX-Iso+P188 (p = 0.0267) | |
MDX - Iso | 5 | 63 | 59 - 73 | |||
MDX - Iso + P188 | 6 | 66 | 57 - 71 |