Table 2 Parametric comparisons of cardiac parameters after 2 weeks of exposure to isoproterenol and treatment with P188 in BL10 and mdx mice.
Measurement | Group | N | Mean ± SD | Overall p-value | Significantly different groups |
|---|---|---|---|---|---|
SF% | BL10 - Untx | 3 | 31.47 ± 0.56 | BL10-Untx vs. BL10-Iso (p < 0.001) | |
BL10 - Iso | 7 | 49.33 ± 3.87 | <0.0001 | BL10-Untx vs. MDX-Iso+P188 (p = 0.001) BL10-Iso vs. MDX-Untx (p < 0.001) | |
MDX - Untx | 6 | 30.31 ± 2.50 | BL10-Iso vs. MDX-Iso (p < 0.001) | ||
MDX - Iso | 10 | 38.06 ± 4.81 | BL10-Iso vs. MDX-Iso+P188 (p = 0.019) | ||
MDX - Iso + P188 | 9 | 42.95 ± 3.27 | MDX-Untx vs. MDX-Iso (p = 0.003) MDX-Untx vs. MDX-Iso+P188 (p < 0.001) | ||
LVID (d) (mm) | BL10 - Untx | 3 | 4.07 ± 0.35 | ||
BL10 - Iso | 7 | 3.70 ± 0.14 | |||
MDX - Untx | 6 | 3.84 ± 0.27 | 0.0011 | BL10-Untx vs. MDX-Iso+P188 (p = 0.007) MDX-Untx vs. MDX-Iso+P188 (p = 0.030) | |
MDX - Iso | 10 | 3.42 ± 0.37 | |||
MDX - Iso + P188 | 9 | 3.37 ± 0.22 | |||
LVPW (d) (mm) | BL10 - Untx | 3 | 0.56 ± 0.01 | BL10-Untx vs. BL10-Iso (p = 0.001) | |
BL10 - Iso | 7 | 0.85 ± 0.07 | BL10-Untx vs. MDX-Iso (p = 0.001) | ||
MDX - Untx | 6 | 0.60 ± 0.09 | <0.0001 | BL10-Untx vs. MDX-Iso+P188 (p < 0.001) BL10-Iso vs. MDX-Untx (p = 0.001) | |
MDX - Iso | 10 | 0.88 ± 0.14 | MDX-Untx vs. MDX-Iso (p < 0.001) | ||
MDX - Iso + P188 | 9 | 0.94 ± 0.07 | MDX-Untx vs. MDX-Iso+P188 (p < 0.001) | ||
LV mass (mg) | BL10 - Untx | 3 | 77.48 ± 1.60 | BL10-Untx vs. BL10-Iso (p = 0.002) | |
BL10 - Iso | 7 | 105.7 ± 12.22 | BL10-Iso vs. MDX-Untx (p < 0.001) | ||
MDX - Untx | 6 | 73.16 ± 9.55 | <0.0001 | BL10-Iso vs. MDX-Iso (p < 0.001) | |
MDX - Iso | 10 | 81.84 ± 9.62 | BL10-Iso vs. MDX-Iso+P188 (p = 0.003 | ||
MDX - Iso + P188 | 9 | 85.26 ± 9.21 | |||
AoV vel (mm/s) | BL10 - Untx | 3 | 1107 ± 49 | ||
BL10 - Iso | 7 | 1194 ± 152 | BL10-Iso vs. MDX-Iso (p = 0.003) | ||
MDX - Untx | 6 | 943 ± 67 | <0.0001 | MDX-Untx vs. MDX-Iso+P188 (p = 0.001) | |
MDX - Iso | 10 | 885 ± 195 | MDX-Iso vs. MDX-Iso+P188 (p < 0.001) | ||
MDX - Iso + P188 | 9 | 1317 ± 150 | |||
Systolic BP (mmHg) | BL10 - Untx | 3 | 92 ± 6 | ||
BL10 - Iso | 7 | 107 ± 5 | BL10-Iso vs. MDX-Untx (p = 0.023) | ||
MDX - Untx | 3 | 88 ± 3 | 0.0005 | BL10-Iso vs. MDX-Iso (p < 0.001) | |
MDX - Iso | 5 | 82 ± 5 | BL10-Iso vs. MDX-Iso+P188 (p = 0.031) | ||
MDX - Iso + P188 | 6 | 92 ± 13 |