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Table 1 Baseline Clinical and Imaging Characteristics and Univariate Analysis from Cox Proportional Hazards Regression

From: Final 2 year results of the vascular imaging of acute stroke for identifying predictors of clinical outcome and recurrent ischemic eveNts (VISION) study

 

Percentage of Group (N = 334)

Progression Hazard Ratio (95% CI)

P-value (FDR)

Recurrence Hazard Ratio (95% CI)

P-value (FDR)

Death Hazard Ratio (95% CI)

P-value (FDR)

NIHSS > 5

31.4

1.1 (0.5, 2.4)

0.74

1.3 (0.5, 3.0)

0.59

9.3 (3.1, 27.8)

< 0.001

Age > 75 years

34.4

0.8 (0.4, 1.9)

0.68 (0.86)

1.6 (0.7, 3.7)

0.26 (0.58)

8.3 (2.8, 24.8)

< 0.001 (0.001)

Male sex

58.1

1.0 (0.5, 2.2)

0.91 (0.95)

3.4 (1.1, 9.9)

0.026 (0.07)

0.8 (0.3, 2.1)

0.72 (0.77)

Hypertension history

60.0

1.1 (0.5, 2.3)

0.80 (0.86)

1.9 (0.8, 4.9)

0.16 (0.31)

1.3 (0.5, 3.1)

0.63 (0.77)

Diabetes mellitus history

15.0

1.9 (0.8, 4.4)

0.14 (0.23)

2.6 (1.1, 6.3)

0.035 (0.12)

1.9 (0.7, 5.3)

0.20 (0.42)

Coronary artery disease history

12.9

0.0 (---, ---)

0.98 (1.00)

0.6 (0.1, 2.6)

0.52 (0.79)

1.2 (0.3, 4.0)

0.79 (0.77)

Systolic BP > 140 or diastolic BP > 90

69.5

2.1 (0.8, 5.6)

0.12 (0.22)

1.3 (0.5, 3.2)

0.62 (0.79)

2.5 (0.7, 8.7)

0.14 (0.30)

Glucose > 8 mmol/L

18.0

2.5 (1.2, 5.4)

0.019 (0.06)

3.9 (1.7, 8.8)

0.001 (0.014)

3.2 (1.3, 7.7)

0.012 (0.06)

Treated with thrombolytic therapy

21.3

0.4 (0.1, 1.4)

0.15 (0.23)

1.0 (0.4, 2.8)

0.94 (0.95)

2.4 (1.0, 6.0)

0.051 (0.13)

Acute stroke on NCCT

34.1

1.4 (0.7, 2.9)

0.39 (0.53)

0.8 (0.3, 2.1)

0.71 (0.81)

1.2 (0.5, 3.1)

0.62 (0.77)

DWI lesion (one or more vs none)

68.0

6.5 (1.5, 27.3)

0.011 (0.013

2.3 (0.8, 6.8)

0.13 (0.30)

1.9 (0.6, 5.7)

0.25 (0.44)

Intracranial occlusion

21.6

5.4 (2.6, 11.3)

< 0.001 (< 0.001)

0.8 (0.3, 2.3)

0.69 (0.79)

1.6 (0.6, 4.2)

0.32 (0.57)

DWI/MTT mismatch

21.3

2.0 (0.9, 4.3)

0.075 (0.17)

1.1 (0.4, 2.9)

0.90 (0.95)

1.3 (0.5, 3.5)

0.65 (0.77)

White matter disease on MRI

70.0

1.1 (0.5, 2.6)

0.75 (0.86)

2.0 (0.7, 6.0)

0.19 (0.31)

3.9 (0.9, 16.9)

0.067 (0.13)

Microbleeds

23.6

1.7 (0.8, 3.7)

0.17 (0.23)

2.2 (1.0, 5.1)

0.061 (0.21)

2.9 (1.2, 6.8)

0.021 (0.10)

Symptomatic ICA stenosis

15.3

3.1 (1.4, 6.6)

0.004 (0.013)

3.3 (1.4, 7.7)

0.007 (0.05)

1.5 (0.5, 4.4)

0.48 (0.77)

  1. FDR = False Discovery Rate p-value adjusting for multiple testing
  2. Test of interaction with dichotomized NIHSS score p-value: Progression (DWI lesion = 0.10, Intracranial occlusion = 0.011); Recurrence (Symptomatic ICA stenosis = 0.05); Death (Age = 0.049)
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