Skip to main content

Table 1 Baseline Clinical and Imaging Characteristics and Univariate Analysis from Cox Proportional Hazards Regression

From: Final 2 year results of the vascular imaging of acute stroke for identifying predictors of clinical outcome and recurrent ischemic eveNts (VISION) study

  Percentage of Group (N = 334) Progression Hazard Ratio (95% CI) P-value (FDR) Recurrence Hazard Ratio (95% CI) P-value (FDR) Death Hazard Ratio (95% CI) P-value (FDR)
NIHSS > 5 31.4 1.1 (0.5, 2.4) 0.74 1.3 (0.5, 3.0) 0.59 9.3 (3.1, 27.8) < 0.001
Age > 75 years 34.4 0.8 (0.4, 1.9) 0.68 (0.86) 1.6 (0.7, 3.7) 0.26 (0.58) 8.3 (2.8, 24.8) < 0.001 (0.001)
Male sex 58.1 1.0 (0.5, 2.2) 0.91 (0.95) 3.4 (1.1, 9.9) 0.026 (0.07) 0.8 (0.3, 2.1) 0.72 (0.77)
Hypertension history 60.0 1.1 (0.5, 2.3) 0.80 (0.86) 1.9 (0.8, 4.9) 0.16 (0.31) 1.3 (0.5, 3.1) 0.63 (0.77)
Diabetes mellitus history 15.0 1.9 (0.8, 4.4) 0.14 (0.23) 2.6 (1.1, 6.3) 0.035 (0.12) 1.9 (0.7, 5.3) 0.20 (0.42)
Coronary artery disease history 12.9 0.0 (---, ---) 0.98 (1.00) 0.6 (0.1, 2.6) 0.52 (0.79) 1.2 (0.3, 4.0) 0.79 (0.77)
Systolic BP > 140 or diastolic BP > 90 69.5 2.1 (0.8, 5.6) 0.12 (0.22) 1.3 (0.5, 3.2) 0.62 (0.79) 2.5 (0.7, 8.7) 0.14 (0.30)
Glucose > 8 mmol/L 18.0 2.5 (1.2, 5.4) 0.019 (0.06) 3.9 (1.7, 8.8) 0.001 (0.014) 3.2 (1.3, 7.7) 0.012 (0.06)
Treated with thrombolytic therapy 21.3 0.4 (0.1, 1.4) 0.15 (0.23) 1.0 (0.4, 2.8) 0.94 (0.95) 2.4 (1.0, 6.0) 0.051 (0.13)
Acute stroke on NCCT 34.1 1.4 (0.7, 2.9) 0.39 (0.53) 0.8 (0.3, 2.1) 0.71 (0.81) 1.2 (0.5, 3.1) 0.62 (0.77)
DWI lesion (one or more vs none) 68.0 6.5 (1.5, 27.3) 0.011 (0.013 2.3 (0.8, 6.8) 0.13 (0.30) 1.9 (0.6, 5.7) 0.25 (0.44)
Intracranial occlusion 21.6 5.4 (2.6, 11.3) < 0.001 (< 0.001) 0.8 (0.3, 2.3) 0.69 (0.79) 1.6 (0.6, 4.2) 0.32 (0.57)
DWI/MTT mismatch 21.3 2.0 (0.9, 4.3) 0.075 (0.17) 1.1 (0.4, 2.9) 0.90 (0.95) 1.3 (0.5, 3.5) 0.65 (0.77)
White matter disease on MRI 70.0 1.1 (0.5, 2.6) 0.75 (0.86) 2.0 (0.7, 6.0) 0.19 (0.31) 3.9 (0.9, 16.9) 0.067 (0.13)
Microbleeds 23.6 1.7 (0.8, 3.7) 0.17 (0.23) 2.2 (1.0, 5.1) 0.061 (0.21) 2.9 (1.2, 6.8) 0.021 (0.10)
Symptomatic ICA stenosis 15.3 3.1 (1.4, 6.6) 0.004 (0.013) 3.3 (1.4, 7.7) 0.007 (0.05) 1.5 (0.5, 4.4) 0.48 (0.77)
  1. FDR = False Discovery Rate p-value adjusting for multiple testing
  2. Test of interaction with dichotomized NIHSS score p-value: Progression (DWI lesion = 0.10, Intracranial occlusion = 0.011); Recurrence (Symptomatic ICA stenosis = 0.05); Death (Age = 0.049)