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Table 6 Addition of Risk Markers to the FRS: Effect on Risk Prediction in Black Women

From: The contribution of a 9p21.3 variant, a KIF6 variant, and C-reactive protein to predicting risk of myocardial infarction in a prospective study

Markers Added
to FRS Model
Number Reclassified (%) Net Number Reclassified
Correctly (NRI, P value)
AUC (P value)*
9p21 110 (27.2) 12 (0.013, 0.89) 0.734 (0.40)
KIF6 11 (2.7) -1 (-0.023, 0.35) 0.723 (0.94)
CRP 31 (7.7) 13 (0.016, 0.70) 0.726 (0.63)
CRP + 9p21 118 (29.1) 14 (0.039, 0.70) 0.735 (0.39)
CRP + KIF6 33 (8.1) 9 (0.025, 0.60) 0.725 (0.83)
9p21 + KIF6 113 (27.9) 15 (0.042, 0.66) 0.733 (0.46)
CRP + 9p21 + KIF6 119 (29.3) 15 (0.002,0.99) 0.734 (0.46)
  1. * P value for change in AUC from AUC of the FRS model (0.723)