The contribution of a 9p21.3 variant, a KIF6 variant, and C-reactive protein to predicting risk of myocardial infarction in a prospective study

Table 5 Addition of Risk Markers to the FRS: Effect on Risk Prediction in Black Men

Markers Added to FRS Model	Number Reclassified (%)	Net Number Reclassified Correctly (NRI, P value)	AUC (P value)*
9p21	50 (21.9)	10 (0.182, 0.02)	0.688 (0.07)
KIF6	no data†	no data†	no data†
CRP	48 (21.1)	-4 (0.006, 0.94)	0.654 (0.92)
CRP + 9p21	70 (30.7)	10 (0.129, 0.16)	0.675 (0.51)
CRP + KIF6	no data†	no data†	no data†
9p21 + KIF6	no data†	no data†	no data†
CRP + 9p21 + KIF6	no data†	no data†	no data†

* P value for change in AUC from AUC of the FRS model (0.657)
†Risk for KIF6 cannot be calculated because none of the 15 African American men who were noncarriers of the KIF6 719Arg risk allele had an event.

ISSN: 1471-2261