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Table 5 Addition of Risk Markers to the FRS: Effect on Risk Prediction in Black Men

From: The contribution of a 9p21.3 variant, a KIF6 variant, and C-reactive protein to predicting risk of myocardial infarction in a prospective study

Markers Added
to FRS Model
Number Reclassified (%) Net Number Reclassified
Correctly (NRI, P value)
AUC (P value)*
9p21 50 (21.9) 10 (0.182, 0.02) 0.688 (0.07)
KIF6 no data† no data† no data†
CRP 48 (21.1) -4 (0.006, 0.94) 0.654 (0.92)
CRP + 9p21 70 (30.7) 10 (0.129, 0.16) 0.675 (0.51)
CRP + KIF6 no data† no data† no data†
9p21 + KIF6 no data† no data† no data†
CRP + 9p21 + KIF6 no data† no data† no data†
  1. * P value for change in AUC from AUC of the FRS model (0.657)
  2. †Risk for KIF6 cannot be calculated because none of the 15 African American men who were noncarriers of the KIF6 719Arg risk allele had an event.