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Table 3 Addition of Risk Markers to the FRS: Effect on Risk Prediction in White Women

From: The contribution of a 9p21.3 variant, a KIF6 variant, and C-reactive protein to predicting risk of myocardial infarction in a prospective study

Markers Added to FRS Model Number Reclassified (%) Net Number Reclassified
Correctly (NRI, P value)
AUC (P value)*
9p21.3 222 (10.3) -16 (-0.018, 0.39) 0.621 (0.57)
KIF6 72 (3.3) 0 (0.007, 0.61) 0.618 (0.57)
CRP 270 (12.5) -10 (-0.032, 0.19) 0.617 (0.69)
CRP + 9p21.3 362 (16.8) 20 (0.007, 0.81) 0.620 (0.81)
CRP + KIF6 276 (12.8) -4 (-0.029, 0.24) 0.617 (0.67)
9p21.3 + KIF6 246 (11.4) -2 (0.015, 0.52) 0.620 (0.65)
CRP + 9p21.3 + KIF6 357 (16.6) 3 (-0.002, 0.95) 0.620 (0.81)
  1. * P value for change in the AUC from the AUC of the FRS model (0.619)