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Table 3 Addition of Risk Markers to the FRS: Effect on Risk Prediction in White Women

From: The contribution of a 9p21.3 variant, a KIF6 variant, and C-reactive protein to predicting risk of myocardial infarction in a prospective study

Markers Added to FRS Model

Number Reclassified (%)

Net Number Reclassified

Correctly (NRI, P value)

AUC (P value)*

9p21.3

222 (10.3)

-16

(-0.018, 0.39)

0.621 (0.57)

KIF6

72 (3.3)

0

(0.007, 0.61)

0.618 (0.57)

CRP

270 (12.5)

-10

(-0.032, 0.19)

0.617 (0.69)

CRP + 9p21.3

362 (16.8)

20

(0.007, 0.81)

0.620 (0.81)

CRP + KIF6

276 (12.8)

-4

(-0.029, 0.24)

0.617 (0.67)

9p21.3 + KIF6

246 (11.4)

-2

(0.015, 0.52)

0.620 (0.65)

CRP + 9p21.3 + KIF6

357 (16.6)

3

(-0.002, 0.95)

0.620 (0.81)

  1. * P value for change in the AUC from the AUC of the FRS model (0.619)