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Table 2 Addition of Risk Markers to the FRS: Effect on Risk Prediction in White Men

From: The contribution of a 9p21.3 variant, a KIF6 variant, and C-reactive protein to predicting risk of myocardial infarction in a prospective study

Markers Added
to FRS Model
Number Reclassified (%) Net Number Reclassified
Correctly (NRI, P value)
AUC (P value)*
9p21.3 205 (13.7) 25 (0.021, 0.41) 0.586 (0.35)
KIF6 309 (20.7) 33 (0.027, 0.32) 0.596 (0.03)
CRP 346 (23.1) 10 (-0.017, 0.61) 0.595 (0.15)
CRP + 9p21.3 412 (27.6) 56 (0.029, 0.40) 0.599 (0.09)
CRP + KIF6 466 (31.2) 86 (0.093, 0.008) 0.608 (0.02)
9p21.3 + KIF6 348 (23.3) 40 (0.041, 0.18) 0.600 (0.03)
CRP + 9p21.3 + KIF6 495 (33.1) 93 (0.076, 0.04) 0.612 (0.01)
  1. * P value for change in the AUC from the AUC of the FRS model (0.581)