Hypothermic effects of DHC infusion in monkeys. Temperature profiles in conscious calves during intravenous infusion of various amounts of the transient receptor potential vanilloid type 1 agonist dihydrocapsaicin (n = 8) or control (n = 2). Target temperature of ΔT = -3 to -5°C are shown as shaded area. Statistics: Blood temperature was compared by a 2-way ANOVA followed by Bonferroni's post-test: ***p < 0.001 at t = 0.5 to 14 hours. Values are expressed as average ± SE, see Methods for further details.