Hypothermic effects of DHC infusion in rats. (A) Dose-response temperature profiles in conscious rats during 6 hour intravenous infusion of the transient receptor potential vanilloid type 1 agonist dihydrocapsaicin at doses of 0.125, 0.25, 0.50, and 0.75 mg/kg/h. (B) Area under the curve during the infusion (t = 0 to 6 hours). Statistics: Each of the transient receptor potential vanilloid type 1 agonists were compared to the vehicle control by an unpaired student's t-test ***p < 0.001, **p < 0.01. Values are expressed as average ± SE, with n = 5, see Methods for further details.