Effect of TRPV1 agonist on temperature in rat. (A) Temperature profiles for transient receptor potential vanilloid type 1 agonists dihydrocapsaicin, resiniferatoxin, olvanil, arvanil, MSK-195 and rinvanil, and vehicle control during 4 hour intravenous administration to conscious rats. (B) Area under the curve during the infusion (t = 0 to 4 hours). Statistics: Each of the transient receptor potential vanilloid type 1 agonists were compared to the vehicle control by an unpaired student's t-test ***p < 0.001, **p < 0.01. Values are expressed as average ± SE, with n = 2 - 6, see Methods for further details.