65) women (odds ratio 3.4, p = 0.013). The INSIG2 SNP was not associated with BMI, nor with other clinical variables. Conclusion Age and gender may influence the association of the INSIG2 obesity SNP with PVD and cerebrovascular disease in patients with pre-existing CVD."/>
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Table 5 Logistic regression risk models for PVD, cerebrovascular disease, and hypercholesterolemia.

From: Association of an INSIG2 obesity allele with cardiovascular phenotypes is gender and age dependent

Characteristic
(age and gender group)
Adjusted Odds Ratio
(CC & GC/GG)
95% C.I. P-value Variables used in model
PVD
(men, age >= 65)
3.4 1.3, 8.8 0.013 History of hypercholesterolemia, history of hypertension, cerebrovascular disease, history of diabetes, BMI
History of Hypercholesterolemia
(men, age < 65)
0.7 0.4, 1.2 0.23 PVD, history of hypertension, cerebrovascular disease, history of diabetes, BMI
Cerebrovascular disease
(women, age >= 65)
5.5 1.1, 27.7 0.04 History of hypercholesterolemia, PVD, history of diabetes, BMI
History of Hypercholesterolemia
(women, age < 65)
0.4 0.2, 1.0 0.07 PVD, history of hypertension, cerebrovascular disease, history of diabetes, BMI