65) women (odds ratio 3.4, p = 0.013). The INSIG2 SNP was not associated with BMI, nor with other clinical variables. Conclusion Age and gender may influence the association of the INSIG2 obesity SNP with PVD and cerebrovascular disease in patients with pre-existing CVD."/>
From: Association of an INSIG2 obesity allele with cardiovascular phenotypes is gender and age dependent
Characteristic (age and gender group) | Adjusted Odds Ratio (CC & GC/GG) | 95% C.I. | P-value | Variables used in model |
---|---|---|---|---|
PVD (men, age >= 65) | 3.4 | 1.3, 8.8 | 0.013 | History of hypercholesterolemia, history of hypertension, cerebrovascular disease, history of diabetes, BMI |
History of Hypercholesterolemia (men, age < 65) | 0.7 | 0.4, 1.2 | 0.23 | PVD, history of hypertension, cerebrovascular disease, history of diabetes, BMI |
Cerebrovascular disease (women, age >= 65) | 5.5 | 1.1, 27.7 | 0.04 | History of hypercholesterolemia, PVD, history of diabetes, BMI |
History of Hypercholesterolemia (women, age < 65) | 0.4 | 0.2, 1.0 | 0.07 | PVD, history of hypertension, cerebrovascular disease, history of diabetes, BMI |