65) women (odds ratio 3.4, p = 0.013). The INSIG2 SNP was not associated with BMI, nor with other clinical variables. Conclusion Age and gender may influence the association of the INSIG2 obesity SNP with PVD and cerebrovascular disease in patients with pre-existing CVD."/>
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Table 4 Association of INSIG2 obesity allele and cardiovascular phenotypes by gender and age.

From: Association of an INSIG2 obesity allele with cardiovascular phenotypes is gender and age dependent

   Men, Age ≥ 65   
  Total CC & GC GG   Adjusted p-value
Characteristic (N = 290) (N = 171) (N = 119) p_value  
Body mass index (kg/m2), mean, median 27.7, 27 27.8, 27 27.6, 27 0.92 1.0000
History Hypercholesterolemia, % 82.6 82.2 83.2 0.83 1.0000
Prior MI, % 28.7 25.7 33.0 0.18 0.7200
Cerebrovascular, % 12.2 14.2 9.3 0.21 0.7200
PVD, % 10.5 14.2 5.1 0.01 0.0500
   Men, Age < 65   
  Total CC & GC GG   Adjusted p-value
Characteristic (N = 377) (N = 195) (N = 182) p_value  
Body mass index (kg/m2), mean, median 30.5, 30 30.2, 30 30.8, 30 0.30 0.9000
History Hypercholesterolemia, % 77.5 74.6 80.6 0.17 0.8500
Prior MI, % 25.4 22.7 28.3 0.21 0.8500
Cerebrovascular, % 3.5 4.1 2.7 0.46 0.9000
PVD, % 5.6 6.7 4.4 0.33 0.9000
   Women, Age ≥ 65   
Characteristic Total CC & GC GG p_value Adjusted p-value
  (N = 151) (N = 79) (N = 72)   
Body mass index (kg/m2), mean, median 29.6, 29 29.5, 29 29.7, 29 0.83 1.0000
History Hypercholesterolemia, % 81.1 78.9 83.3 0.50 1.0000
Prior MI, % 22.7 20.5 25.0 0.53 1.0000
Cerebrovascular, % 8.0 12.8 2.8 0.02 0.1000
PVD, % 8.0 7.7 8.3 0.88 1.0000
   Women, Age < 65   
Characteristic Total CC & GC GG p_value Adjusted p-value
  (N = 127) (N = 61) (N = 66)   
Body mass index (kg/m2), mean, median 32.3, 31 31.5, 30 33.1, 32 0.2105 0.8420
History Hypercholesterolemia, % 75.6 67.2 83.1 0.0412 0.2060
Prior MI, % 16.5 12.3 20.3 0.2351 0.8420
Cerebrovascular, % 4.8 5.2 4.5 0.8710 0.8710
PVD, % 5.6 3.4 7.6 0.3204 0.8420