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Table 4 Association of INSIG2 obesity allele and cardiovascular phenotypes by gender and age.

From: Association of an INSIG2 obesity allele with cardiovascular phenotypes is gender and age dependent

   Men, Age ≥ 65   
  Total CC & GC GG   Adjusted p-value
Characteristic (N = 290) (N = 171) (N = 119) p_value  
Body mass index (kg/m2), mean, median 27.7, 27 27.8, 27 27.6, 27 0.92 1.0000
History Hypercholesterolemia, % 82.6 82.2 83.2 0.83 1.0000
Prior MI, % 28.7 25.7 33.0 0.18 0.7200
Cerebrovascular, % 12.2 14.2 9.3 0.21 0.7200
PVD, % 10.5 14.2 5.1 0.01 0.0500
   Men, Age < 65   
  Total CC & GC GG   Adjusted p-value
Characteristic (N = 377) (N = 195) (N = 182) p_value  
Body mass index (kg/m2), mean, median 30.5, 30 30.2, 30 30.8, 30 0.30 0.9000
History Hypercholesterolemia, % 77.5 74.6 80.6 0.17 0.8500
Prior MI, % 25.4 22.7 28.3 0.21 0.8500
Cerebrovascular, % 3.5 4.1 2.7 0.46 0.9000
PVD, % 5.6 6.7 4.4 0.33 0.9000
   Women, Age ≥ 65   
Characteristic Total CC & GC GG p_value Adjusted p-value
  (N = 151) (N = 79) (N = 72)   
Body mass index (kg/m2), mean, median 29.6, 29 29.5, 29 29.7, 29 0.83 1.0000
History Hypercholesterolemia, % 81.1 78.9 83.3 0.50 1.0000
Prior MI, % 22.7 20.5 25.0 0.53 1.0000
Cerebrovascular, % 8.0 12.8 2.8 0.02 0.1000
PVD, % 8.0 7.7 8.3 0.88 1.0000
   Women, Age < 65   
Characteristic Total CC & GC GG p_value Adjusted p-value
  (N = 127) (N = 61) (N = 66)   
Body mass index (kg/m2), mean, median 32.3, 31 31.5, 30 33.1, 32 0.2105 0.8420
History Hypercholesterolemia, % 75.6 67.2 83.1 0.0412 0.2060
Prior MI, % 16.5 12.3 20.3 0.2351 0.8420
Cerebrovascular, % 4.8 5.2 4.5 0.8710 0.8710
PVD, % 5.6 3.4 7.6 0.3204 0.8420