Table 3 Patient demographics, disease history, and INSIG2 genotypes.
From: Association of an INSIG2 obesity allele with cardiovascular phenotypes is gender and age dependent
Characteristic | Total (N = 947) | CC (N = 94) | GC (N = 413) | GG (N = 440) | p_value | Adjusted p_value |
|---|---|---|---|---|---|---|
Age, mean, median | 64.0, 64 | 64.2, 64 | 65.1, 65 | 63.0, 63 | 0.0571 | 1.0000 |
Female, % | 29.4 | 23.4 | 28.6 | 31.4 | 0.2748 | 1.0000 |
Race, % | ||||||
White | 77.7 | 87.2 | 80.8 | 72.7 | 0.0490 | 1.0000 |
Black | 14.0 | 8.5 | 11.4 | 17.5 | ||
Asian | 1.1 | 0.0 | 1.2 | 1.1 | ||
Hispanic | 7.0 | 4.3 | 6.1 | 8.4 | ||
Other | 0.3 | 0.0 | 0.5 | 0.2 | ||
Height (cm), mean, median | 171.3, 173 | 172.9, 173 | 171.7, 173 | 170.6, 171 | 0.1450 | 1.0000 |
Weight (kg), mean, median | 87.3, 85 | 89.1, 87 | 86.6, 85 | 87.5, 85 | 0.4407 | 1.0000 |
Body mass index (kg/m2), mean, median | 29.7, 29 | 29.6, 29 | 29.4, 28 | 30.1, 29 | 0.1616 | 1.0000 |
Smoking, % | ||||||
Never | 35.3 | 34.5 | 36.9 | 34.0 | 0.9078 | 1.0000 |
Current | 24.1 | 23.0 | 23.3 | 25.1 | ||
Former | 40.6 | 42.5 | 39.7 | 40.9 | ||
Patient previously treated with a stent, % | 32.4 | 37.2 | 30.1 | 33.5 | 0.3268 | 1.0000 |
History of in-stent restenosis, % | 23.3 | 26.5 | 22.6 | 23.1 | 0.8909 | 1.0000 |
Stent type | ||||||
Coated, % | 16.0 | 19.1 | 13.1 | 18.0 | 0.1020 | 1.0000 |
Uncoated, % | 9.6 | 12.8 | 10.7 | 8.0 | 0.2266 | 1.0000 |
Prior CABG, % | ||||||
None | 81.4 | 79.8 | 80.3 | 82.6 | 0.8098 | 1.0000 |
One | 16.8 | 19.1 | 17.5 | 15.8 | ||
More than one | 1.8 | 1.1 | 2.2 | 1.6 | ||
Acute MI | 25.2 | 23.4 | 27.5 | 23.4 | 0.4472 | 1.0000 |
Prior MI, % | 24.9 | 31.5 | 20.3 | 27.8 | 0.0131 | 0.2882 |
History Diabetes, % | 37.4 | 29.8 | 38.0 | 38.5 | 0.2716 | 1.0000 |
History Cerebrovascular, % | 7.0 | 5.3 | 9.9 | 4.8 | 0.0125 | 0.2875 |
History Renal Disease, % | 9.9 | 9.6 | 9.9 | 10.0 | 0.9902 | 1.0000 |
History Chest Pain (angina), % | 54.3 | 57.4 | 53.4 | 54.5 | 0.7716 | 1.0000 |
History PVD, % | 7.5 | 11.7 | 8.4 | 5.7 | 0.0851 | 1.0000 |
History Pulmonary Disease, % | 8.1 | 7.4 | 8.9 | 7.5 | 0.7500 | 1.0000 |
History Cancer, % | 8.5 | 9.6 | 9.9 | 7.1 | 0.3235 | 1.0000 |
History Hypercholesterolemia, % | 79.4 | 81.7 | 75.9 | 82.2 | 0.0707 | 1.0000 |
History Hypertension, % | 78.2 | 81.7 | 78.5 | 77.0 | 0.5931 | 1.0000 |