65) women (odds ratio 3.4, p = 0.013). The INSIG2 SNP was not associated with BMI, nor with other clinical variables. Conclusion Age and gender may influence the association of the INSIG2 obesity SNP with PVD and cerebrovascular disease in patients with pre-existing CVD."/>
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Table 3 Patient demographics, disease history, and INSIG2 genotypes.

From: Association of an INSIG2 obesity allele with cardiovascular phenotypes is gender and age dependent

Characteristic Total
(N = 947)
CC
(N = 94)
GC
(N = 413)
GG
(N = 440)
p_value Adjusted p_value
Age, mean, median 64.0, 64 64.2, 64 65.1, 65 63.0, 63 0.0571 1.0000
Female, % 29.4 23.4 28.6 31.4 0.2748 1.0000
Race, %       
White 77.7 87.2 80.8 72.7 0.0490 1.0000
Black 14.0 8.5 11.4 17.5   
Asian 1.1 0.0 1.2 1.1   
Hispanic 7.0 4.3 6.1 8.4   
Other 0.3 0.0 0.5 0.2   
Height (cm), mean, median 171.3, 173 172.9, 173 171.7, 173 170.6, 171 0.1450 1.0000
Weight (kg), mean, median 87.3, 85 89.1, 87 86.6, 85 87.5, 85 0.4407 1.0000
Body mass index (kg/m2), mean, median 29.7, 29 29.6, 29 29.4, 28 30.1, 29 0.1616 1.0000
Smoking, %       
Never 35.3 34.5 36.9 34.0 0.9078 1.0000
Current 24.1 23.0 23.3 25.1   
Former 40.6 42.5 39.7 40.9   
Patient previously treated with a stent, % 32.4 37.2 30.1 33.5 0.3268 1.0000
History of in-stent restenosis, % 23.3 26.5 22.6 23.1 0.8909 1.0000
Stent type       
Coated, % 16.0 19.1 13.1 18.0 0.1020 1.0000
Uncoated, % 9.6 12.8 10.7 8.0 0.2266 1.0000
Prior CABG, %       
None 81.4 79.8 80.3 82.6 0.8098 1.0000
One 16.8 19.1 17.5 15.8   
More than one 1.8 1.1 2.2 1.6   
Acute MI 25.2 23.4 27.5 23.4 0.4472 1.0000
Prior MI, % 24.9 31.5 20.3 27.8 0.0131 0.2882
History Diabetes, % 37.4 29.8 38.0 38.5 0.2716 1.0000
History Cerebrovascular, % 7.0 5.3 9.9 4.8 0.0125 0.2875
History Renal Disease, % 9.9 9.6 9.9 10.0 0.9902 1.0000
History Chest Pain (angina), % 54.3 57.4 53.4 54.5 0.7716 1.0000
History PVD, % 7.5 11.7 8.4 5.7 0.0851 1.0000
History Pulmonary Disease, % 8.1 7.4 8.9 7.5 0.7500 1.0000
History Cancer, % 8.5 9.6 9.9 7.1 0.3235 1.0000
History Hypercholesterolemia, % 79.4 81.7 75.9 82.2 0.0707 1.0000
History Hypertension, % 78.2 81.7 78.5 77.0 0.5931 1.0000