Table 1 Clinical observations in healthy rats.
Dose (mg/kg) | 0 | 1.0 | 2.0 | 2.2 | 2.4 | 3.0 |
|---|---|---|---|---|---|---|
Step | 1 | 2 | 3 | 4 | 5 | 6 |
Mortality | -- | -- | -- | -- | -- | -- |
Clinical Observations | ||||||
Apparent restlessness | -- | -- | All | -- | -- | -- |
Increased activity | -- | -- | Rat 2 | -- | -- | Rat 1 |
Circling in cage | -- | -- | Rat 2 | -- | -- | Rat 1 |
Stiff tail | -- | -- | Rat 2 | -- | -- | Rat 1 |
Lateral recumbency | -- | -- | Rat 2 | -- | -- | Rat 1 |
Shallow respiration | -- | -- | -- | -- | -- | Rat 1 |
Muscle tremors, thorax | -- | -- | -- | -- | -- | Rat 1 |
Vocalizing | -- | -- | Rat 5 | -- | -- | -- |
Piloerection | -- | -- | -- | Rat 2 | Rat 2 | Rat 2 |
Red pinnae | -- | -- | -- | All | All | All |