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Table 1 Baseline characteristics (mean ± SD except skewed data where geometric mean (95%CI) shown) stratified by enrollment group and ethnicity

From: Attenuation of microvascular function in those with cardiovascular disease is similar in patients of Indian Asian and European descent

 

No known CAD

Established CAD

P by

Variable

Europeans

Indian Asians

Europeans

Indian Asians

Ethnicity

CAD group

N

41

43

42

41

  

Age (years)

61 ± 7

58 ± 9

67 ± 9

61 ± 8

0.0001

0.0004

Time since diagnosis (days)

  

65 ± 7

72 ± 9

0.08

 

systolic BP (mmHg)

143 ± 21

135 ± 16

144 ± 19

133 ± 15

0.005

0.8

diastolic BP (mmHg)

85 ± 10

84 ± 9

81 ± 8

79 ± 77

0.2

0.003

Heart Rate (bpm)

63 ± 11

65 ± 11

61 ± 9

65 ± 11

0.1

0.5

Weight (kg)

84 ± 15

72 ± 13

86 ± 12

77 ± 10

< 0.0001

0.08

BMI (kg/m2)

28 ± 4

26 ± 4

28 ± 4

27 ± 3

0.0009

0.2

Waist circumference (cm)

100 ± 12

94 ± 10

103 ± 8

100 ± 9

0.004

0.005

Waist:hip ratio

0.99 ± 0.06

0.99 ± 0.10

0.98 ± 0.08

1.01 ± 0.05

0.3

0.8

Fasting insulin* (iu/dl)

41(33-50)

47(39-58)

54(45-64)

66(54-79)

0.06

0.002

Fasting glucose (mmol/l)*

5.5(5.2 - 5.8)

5.6(5.3-6.0)

5.9(5.5-6.3)

6.2(5.6-6.8)

0.3

0.03

HbA1c (%)*

5.7(5.5-5.9)

6.2(6.0-6.4)

5.9(5.7-6.2)

6.7(6.3-7.1)

< 0.0001

0.006

eGFR (MDRD equation)

73 ± 14

78 ± 12

64 ± 13

68 ± 16

0.1

0.0004

C-Reactive protein(mg/l)*

1.7(1.1-2.7)

1.6(1.1-2.3)

2.3(1.6-3.2)

1.3(1.0-1.8)

0.1

0.7

Total cholesterol (mmol/l)

4.7 ± 1.0

4.8 ± 0.8

4.1 ± 0.9

4.1 ± 1.0

0.99

< 0.0001

HDL cholesterol (mmol/l)

1.17(1.08-1.26)

1.19(1.10-1.28)

1.14(1.06-1.23)

1.04(0.96-1.12)

0.3

0.04

Cholesterol:HDL ratio*

4.0(3.6-4.3)

4.0(3.7-4.2)

3.5(3.3-3.8)

3.8(3.5-4.2)

0.4

0.06

LDL cholesterol (mmol/l)*

2.8(2.5-3.2)

2.8(2.6-3.0)

2.1(1.9-2.4)

2.1(1.9-2.3)

0.9

< 0.0001

Triglycerides (mmol/l)*

1.2(1.1-1.4)

1.2(1.1-1.4)

1.3(1.1-1.5)

1.4(1.2-1.7)

0.4

0.1

Statin therapy n (%)

12(29)

9(21)

36(86)

33(81)

0.3

< 0.0001

Diabetes n (%)

6(15)

10(23)

9(21)

15(37)

0.07

0.1

FHx heart disease n(%)

7(17)

11(25)

21(50)

14(34)

0.6

0.004

Smokers (Current/Ex/Never)

12/20/9

8/12/23

4/29/9

3/16/21

0.0005

0.2

Maximal hyperaemia (au)*

145(130-162)

141(131-153)

117(105-131)

111(101-122)

0.4

< 0.0001

Reactive hyperaemia (au)*

57(49-67)

49(43-56)

44(38-50)

39(34-45)

0.06

0.0007

  1. * Log transformed data
  2. p = significance between disease and control group and between each ethnic group two way analysis of variance (ANOVA), with test for interaction
  3. No known CAD (Coronary artery disease) recruited from general practice register with no documented history of, or medications suggested of coronary artery disease.
  4. Established CAD recruited with established symptomatic atherosclerotic coronary artery with at least one > 50% stenosis and evidence of other atherosclerotic disease on angiography
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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