Safety and efficacy of thrombectomy in patients undergoing primary percutaneous coronary intervention for Acute ST elevation MI: A Meta-Analysis of Randomized Controlled Trials

Tamhane, Umesh U; Chetcuti, Stanley; Hameed, Irfan; Grossman, P Michael; Moscucci, Mauro; Gurm, Hitinder S

doi:10.1186/1471-2261-10-10

Table 1 Baseline characteristics of studies included in the meta-analysis

From: Safety and efficacy of thrombectomy in patients undergoing primary percutaneous coronary intervention for Acute ST elevation MI: A Meta-Analysis of Randomized Controlled Trials

	Svilaas, 2008		AIMI, 2006		DEAR-MI, 2006		Kaltoft, 2006
	Thrombectomy	Control	Thrombectomy	Control	Thrombectomy	Control	Thrombectomy	Control
Number of patients in each arm	535	536	240	240	74	74	108	107
Male (%)	68	73	76	74	84	76	76	80
Age, years (mean ± SD)	63 ± 13	63 ± 13	60	60	57 ± 13	59 ± 14	65 ± 11	63 ± 13
Diabetes (%)	11	13	17	16	21	15	8	6
Glycoprotein IIb/IIIa inhibitor use (%)	93	90	95	94	100	100	96	93
Anterior MI* (%)	43	43	39	37	42	51	46	43
Mean symptom to Balloon time (minutes)	190^a	185^a	306^b	300^b	206	199	242	208
Thrombus (%)	49	44	65^c	58^c	NA	NA	69	79
Follow up duration, days	30	30	30	30	30	30	30	30
Device	Export		Angiojet		Pronto		Rescue
Mechanism	Manual		Mechanical		Manual		Vacuum
Total number of patients, (N)	1071		480		148		215
Primary outcome	MBG		Infarct size		STR, MBG		Myocardial salvage
	De Luca, 2006		X-AMINE ST, 2005		REMEDIA, 2005		VAMPIRE, 2008
	Thrombectomy	Control	Thrombectomy	Control	Thrombectomy	Control	Thrombectomy	Control
Number of patients in each arm	38	38	100	101	50	49	180	175
Male (%)	71	55	76	73	90	78	80.6	77.7
Age, years (mean ± SD)	67 ± 14	65 ± 13	61 ± 13	62 ± 11	61 ± 13	60 ± 13	63.2 ± 11	63.5 ± 10
Diabetes (%)	24	18	25	18	22	18	23.3	29.9
Glycoprotein IIb/IIIa inhibitor use (%)	100	100	55	65	68	63	0	0
Anterior MI* (%)	97	100	54	50	40	51	50	52
Mean symptom to Balloon time (minutes)	432	456	251	264	274	300	376	426
Thrombus (%)	100	100	100	100	58	55	NA	NA
Follow up duration, days	180	180	180	180	30	30	240	240
Device	Diver CE		X-Sizer		Diver CE		TVAC	Export
Mechanism	Manual		Mechanical		Manual		Vacuum	Manual
Total number of patients, (N)	76		201		99		355	50
Primary outcome	LV remodeling		STR		MBG, STR		MBG
	Export, 2005		Dudek, 2004		Antoniucci, 2004		NON STOP, 2004
	Thrombectomy	Control	Thrombectomy	Control	Thrombectomy	Control	Thrombectomy	Control
Number of patients in each arm	24	26	40	32	50	50	138	131
Male (%)	NA	NA	NA	NA	82	78	79	79
Age, years (mean ± SD)	NA	NA	NA	NA	63 ± 13	66 ± 12	64 ± 12	66 ± 11
Diabetes (%)	NA	NA	NA	NA	18	16	NA	NA
Glycoprotein IIb/IIIa inhibitor use (%)	NA	NA	NA	NA	98	98	NA	NA
Anterior MI^¶ (%)	NA	NA	NA	NA	34	46	34	46
Mean symptom to Balloon time
(minutes)	NA	NA	258	236	234	264	NA	NA
Thrombus (%)	NA	NA	100	100	NA	NA	NA	NA
Follow up duration, days	NA	NA	90	90	30	30	NA	NA
Device	Export		Rescue		Angiojet		Rescue
Mechanism	Manual		Vacuum		Mechanical		Vacuum
Total number of patients (N)	50		72		100		269
Primary outcome	STR		TIMI, cTFC, tMPG, STR		STR		NA
	Napodano, 2003		Beran, 2002		Chevalier, 2008		EXPIRA, 2009
	Thrombectomy	Control	Thrombectomy	Control	Thrombectomy	Control	Thrombectomy	Control
Number of patients in each arm	46	46	30	31	120	129	88	87
Male (%)	83	72	73	77	80.8	81.4	64.7	55.1
Age, years (mean ± SD)	61 ± 11	64 ± 12	56 ± 10	54 ± 10	59.2 ± 13	61.2 ± 13	66.7 ± 14	64.6 ± 13
Diabetes (%)	13	13	17	13	16.7	13.2	22.7	18.4
Glycoprotein IIb/IIIa inhibitor use (%)	43	41	73	68	65.8	69.8	100	100
Anterior MI^¶ (%)	39	44	35	35	49.2	55.8	0	0
Mean symptom to Balloon time (minutes)	238^b	204^b	291	279	321.7	271.4	408	456
Thrombus (%)	100	100	100	100	NA	NA	100	100
Follow up duration, days	30	30	30	30	30	30	270	270
Device	X-Sizer		X-Sizer		Export		Export
Mechanism	Mechanical		Mechanical		Manual		Manual
Total number of patients, (N)	92		61		249		175
Primary outcome	MBG		cTFC		STR, MBG		MBG, STR
	PIHRATE, 2007
	Thrombectomy	Control
Number of patients in each arm	102	94
Male (%)	79	81
Age, years (mean ± SD)	61 ± 10	58 ± 10
Diabetes (%)	12	10
Glycoprotein IIb/IIIa inhibitor use (%)	62	63
Anterior MI^¶ (%)	NA	NA
Mean symptom to Balloon time (minutes)	195	206
Thrombus (%)	70	70
Follow up duration, days	180	180
Device	Diver CE
Mechanism	Manual
Total number of patients, (N)	196
Primary outcome	STR

*In the studies with missing anterior MI rate, patients with left anterior descending artery as culprit artery were considered to have anterior MI; a = median; NA = Not available. b = time from symptom onset to emergency department (ED) plus time from ED to randomization; MBG = Myocardial blush grade; cTFC = Corrected TIMI frame count; tMPG = TIMI myocardial perfusion grade; STR = ST-segment resolution; TIMI = Thrombolysis in myocardial infarction grade flow; c = Grade 4 or 5

Back to article page

ISSN: 1471-2261

Contact us

Submission enquiries: bmccardiovasculardisorders@biomedcentral.com
General enquiries: ORSupport@springernature.com

BMC Cardiovascular Disorders

Contact us