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  1. Research article

    Statin use reduces cardiovascular events and all-cause mortality amongst Chinese patients with type 2 diabetes mellitus: a 5-year cohort study

    The benefit of statin on the management of Type 2 Diabetes Mellitus (T2DM) among Chinese patients in primary care is not clear nor fully implemented in clinical practice. This study aimed to evaluate and quant...

    Colman Siu Cheung Fung, Eric Yuk Fai Wan, Anca Ka Chun Chan and Cindy Lo Kuen Lam

    BMC Cardiovascular Disorders 2017 17:166

    Published on: 24 June 2017

  2. Research article

    The neutrophil-to-lymphocyte ratio on admission is a good predictor for all-cause mortality in hypertensive patients over 80 years of age

    Immuno-inflammation plays a major role in the process of hypertension. We aimed to evaluate the association between inflammatory markers, neutrophil-to-lymphocyte ratio (NLR), red cell distribution width (RDW)...

    Xiaonan Sun, Leiming Luo, Xiaoqian Zhao, Ping Ye and Ruixue Du

    BMC Cardiovascular Disorders 2017 17:167

    Published on: 24 June 2017

  3. Research article

    Aging and obesity are associated with undiagnosed hypertension in a cohort of males in the Central Province of Sri Lanka: a cross-sectional descriptive study

    Lifestyle factors associated with hypertension (HT) in South Asian populations are relatively unknown. The objective of the current study was to investigate the prevalence rates of undiagnosed HT and factors a...

    N. W. I. A. Jayawardana, W. A. T. A. Jayalath, W. M. T. Madhujith, U. Ralapanawa, R. S. Jayasekera, S. A. S. B. Alagiyawanna, A. M. K. R. Bandara and N. S. Kalupahana

    BMC Cardiovascular Disorders 2017 17:165

    Published on: 21 June 2017

  4. Research article

    Downregulation of Talin-1 expression associates with increased proliferation and migration of vascular smooth muscle cells in aortic dissection

    This study aimed to assessed whether Talin-1 is involved in the pathogenesis of aortic dissection via regulating vascular smooth muscle cell (VSMC) biological function.

    Xiaolong Wei, Yudong Sun, Yani Wu, Jiang Zhu, Bin Gao, Han Yan, Zhiqing Zhao, Jian Zhou and Zaiping Jing

    BMC Cardiovascular Disorders 2017 17:162

    Published on: 20 June 2017

  5. Research article

    Expression levels of atherosclerosis-associated miR-143 and miR-145 in the plasma of patients with hyperhomocysteinaemia

    An elevated level of homocysteine (Hcy) in the blood is designated hyperhomocysteinaemia (Hhcy) and is regarded as a strong risk factor for the development of atherosclerosis (ATH), although the association re...

    Kejian Liu, Saiyare Xuekelati, Yue Zhang, Yin Yin, Yue Li, Rui Chai, Xinwei Li, Yi Peng, Jiangdong Wu and Xiaomei Guo

    BMC Cardiovascular Disorders 2017 17:163

    Published on: 20 June 2017

  6. Research article

    Cardiac tissue oxidative stress and inflammation after vitamin D administrations in high fat- diet induced obese rats

    Obesity is associated with numerous metabolic and inflammatory disorders. The current study was aimed to evaluate the effects of vitamin D administration on the markers of oxidative stress and inflammation in ...

    Mahdieh Abbasalizad Farhangi, Ghazaleh Nameni, Ghazaleh Hajiluian and Mehran Mesgari-Abbasi

    BMC Cardiovascular Disorders 2017 17:161

    Published on: 19 June 2017

  7. Research article

    DNA methylation dysregulations in rheumatic heart valve disease

    The epigenetic changes underlying the development of rheumatic heart valve disease (RHVD) remain incompletely understood. Limited evidence suggests that abnormal DNA methylation might be involved in the pathog...

    Kangjun Shen, Hui Liu, Ran Jing, Jiangfeng Yi and Xinmin Zhou

    BMC Cardiovascular Disorders 2017 17:159

    Published on: 17 June 2017

  8. Research article

    Prevalence and treatment of atherogenic dyslipidemia in the primary prevention of cardiovascular disease in Europe: EURIKA, a cross-sectional observational study

    Atherogenic dyslipidemia is associated with poor cardiovascular outcomes, yet markers of this condition are often ignored in clinical practice. Here, we address a clear evidence gap by assessing the prevalence...

    Julian P. Halcox, José R. Banegas, Carine Roy, Jean Dallongeville, Guy De Backer, Eliseo Guallar, Joep Perk, David Hajage, Karin M. Henriksson and Claudio Borghi

    BMC Cardiovascular Disorders 2017 17:160

    Published on: 17 June 2017

  9. Research article

    Individualized dual antiplatelet therapy based on platelet function testing in patients undergoing percutaneous coronary intervention: a meta-analysis of randomized controlled trials

    High on-treatment platelet reactivity (HPR) represents a strong risk factor for thrombotic events after PCI. We aim to evaluate the efficacy and safety of individualizing intensified dual antiplatelet therapy ...

    Yijiang Zhou, Yanwei Wang, Yutao Wu, Chaoyang Huang, Hui Yan, Weiguo Zhu, Weiwei Xu, Li Zhang and Jianhua Zhu

    BMC Cardiovascular Disorders 2017 17:157

    Published on: 15 June 2017

  10. Research article

    The influence of dehydration on the prognosis of acute ischemic stroke for patients treated with tissue plasminogen activator

    Many studies have determined that dehydration is an independent predictor of outcome after ischemic stroke (IS); however, none have determined if the use of thrombolytic therapy modifies the negative impact of...

    Fei-Fan Wu, Yen-Chu Hung, Y. H. Tsai, Jen-Tsung Yang, Tsong-Hai Lee, Chia-Wei Liow, Jiann-Der Lee, Chung-Jen Lin, Tsung-I Peng and Leng-Chieh Lin

    BMC Cardiovascular Disorders 2017 17:154

    Published on: 13 June 2017

  11. Research article

    Exploration of the methodological quality and clinical usefulness of a cross-sectional sample of published guidance about exercise training and physical activity for the secondary prevention of coronary heart disease

    Clinicians are encouraged to use guidelines to assist in providing evidence-based secondary prevention to patients with coronary heart disease. However, the expanding number of publications providing guidance ...

    Bridget Abell, Paul Glasziou and Tammy Hoffmann

    BMC Cardiovascular Disorders 2017 17:153

    Published on: 13 June 2017

  12. Research article

    Normal limits of the electrocardiogram derived from a large database of Brazilian primary care patients

    Knowledge of the normal limits of the electrocardiogram (ECG) is mandatory for establishing which patients have abnormal ECGs. No studies have assessed the reference standards for a Latin American population. ...

    Daniel M. F. Palhares, Milena S. Marcolino, Thales M. M. Santos, José L. P. da Silva, Paulo R. Gomes, Leonardo B. Ribeiro, Peter W. Macfarlane and Antonio L. P. Ribeiro

    BMC Cardiovascular Disorders 2017 17:152

    Published on: 13 June 2017

  13. Software

    Unlocking echocardiogram measurements for heart disease research through natural language processing

    In order to investigate the mechanisms of cardiovascular disease in HIV infected and uninfected patients, an analysis of echocardiogram reports is required for a large longitudinal multi-center study.

    Olga V. Patterson, Matthew S. Freiberg, Melissa Skanderson, Samah J. Fodeh, Cynthia A. Brandt and Scott L. DuVall

    BMC Cardiovascular Disorders 2017 17:151

    Published on: 12 June 2017

  14. Research article

    Pulmonary hemodynamics and effects of phosphodiesterase type 5 inhibition in heart failure: a meta-analysis of randomized trials

    Previous studies suggested that phosphodiesterase 5 inhibitors (PDE5i) have a beneficial effect in patients with heart failure (HF), although the results were inconsistent. We performed a meta-analysis to eval...

    In-Chang Hwang, Yong-Jin Kim, Jun-Bean Park, Yeonyee E. Yoon, Seung-Pyo Lee, Hyung-Kwan Kim, Goo-Yeong Cho and Dae-Won Sohn

    BMC Cardiovascular Disorders 2017 17:150

    Published on: 12 June 2017

  15. Research article

    Regional and hospital variations in the extent of decline in the proportion of percutaneous coronary interventions performed for nonacute indications – a nationwide population-based study

    The volume and percentage of percutaneous coronary interventions (PCIs) performed for nonacute indications have declined in the United States since 2007. However, little is known if similar trends occurred in ...

    Fu-Wen Liang, Tsung-Hsueh Lu, Hsin-Min Wu, Jo-Chi Lee and Wei-Hsian Yin

    BMC Cardiovascular Disorders 2017 17:149

    Published on: 9 June 2017

  16. Research article

    Long-term outcome of bioresorbable vascular scaffolds for the treatment of coronary artery disease: a meta-analysis of RCTs

    Coronary bioresorbable scaffolds (BRS) were developed to overcome the limitations of standard metallic stents, especially to address late events after percutaneous coronary interventions. The aim of this meta-...

    Alberto Polimeni, Remzi Anadol, Thomas Münzel, Ciro Indolfi, Salvatore De Rosa and Tommaso Gori

    BMC Cardiovascular Disorders 2017 17:147

    Published on: 7 June 2017

  17. Study protocol

    Design and rationale for the WARFA trial: a randomized controlled cross-over trial testing the therapeutic equivalence of branded and generic warfarin in atrial fibrillation patients in Brazil

    Warfarin is a commonly used anticoagulant. Whether a given dose of the different formulations of Brazilian warfarin will result in the same effect on the international normalized ratio (INR) is uncertain. The ...

    Carolina Gomes Freitas, Michael Walsh and Álvaro Nagib Atallah

    BMC Cardiovascular Disorders 2017 17:148

    Published on: 7 June 2017

  18. Research article

    Does the presence of cardiovascular disease risk factors or established disease influence the dietary intake of affected adults and their children residing in the same household? A secondary analysis of the Australian Health Survey (2011–2013)

    Diet is an important contributor to risk of cardiovascular disease (CVD) and integral in management and delaying progression. Little is known however about whether increased CVD risk or established CVD has any...

    Jolene Thomas, Lily Chan, Amanda Wray, Jacqueline Miller, Kaye Mehta, Alison Yaxley, Kacie Dickinson, Louisa Matwiejczyk, Kathryn Jackson and Michelle Miller

    BMC Cardiovascular Disorders 2017 17:146

    Published on: 5 June 2017

  19. Research article

    Volume-time curve of cardiac magnetic resonance assessed left ventricular dysfunction in coronary artery disease patients with type 2 diabetes mellitus

    Type 2 diabetes mellitus (DM2) may induce epicardial coronary artery diseases and left ventricular myocardial damaging as well. Left ventricular dysfunction was found in DM2. In this research, we compared the ...

    Hua-yan Xu, Zhi-gang Yang, Ying-kun Guo, Ke Shi, Xi Liu, Qin Zhang, Li Jiang and Lin-jun Xie

    BMC Cardiovascular Disorders 2017 17:145

    Published on: 5 June 2017

  20. Research article

    Deactivation vs. asynchronous pacing - prospective evaluation of a protocol for rhythm management in patients with magnetic resonance conditional pacemakers undergoing adenosine stress cardiovascular magnetic resonance imaging

    Cardiovascular Magnetic Resonance (CMR) imaging with adenosine stress is an important diagnostic tool in patients with known or suspected coronary artery disease (CAD). However, the method is not yet establish...

    Oliver Klein-Wiele, Marietta Garmer, Gianluca Barbone, Rhyan Urbien, Martin Busch, Kaffer Kara, Harald Schäfer, Michael Schulte-Hermes, Birgit Hailer and Dietrich Grönemeyer

    BMC Cardiovascular Disorders 2017 17:142

    Published on: 2 June 2017

  21. Research article

    Macrophage migration inhibitory factor promoter polymorphisms (−794 CATT5–8): Relationship with soluble MIF levels in coronary atherosclerotic disease subjects

    We analyzed the relationship of −794 CATT5–8 MIF polymorphisms with soluble MIF in Coronary Atherosclerotic Disease (CAD) patients.

    Lu Qian, Xiao-Yan Wang, Saroj Thapa, Lu-yuan Tao, Shao-Ze Wu, Gao-Jiang Luo, Lu-Ping Wang, Jiao-Ni Wang, Jie Wang, Ji Li, Ji-Fei Tang and Kang-Ting Ji

    BMC Cardiovascular Disorders 2017 17:144

    Published on: 2 June 2017

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