Skip to main content
Download PDF
  • Research article
  • Open access
  • Published:

Gender based differences in drug eluting stent implantation - data from the German ALKK registry suggest underuse of DES in elderly women

BMC Cardiovascular Disorders volume 17, Article number: 68 (2017) Cite this article

Abstract

Background

Observational studies suggest there are gender based differences in the treatment of coronary artery disease, with women receiving evidence based therapy less frequently than suggested by current guidelines. The aim of our study was to evaluate gender based differences in the use of DES.

Methods

We analysed prospectively collected data from 100704 stent implantations in the PCI registry of the ALKK between 2005 and 2009.

Results

The usage of DES increased from 16.0 to 43.9%. Although women had smaller vessel sizes, they received DES less often compared to men (28.2 vs. 31.3%), with an adjusted odds ratio of 0.93 (95% confidence interval 0.89-0.97) at the age of 75, and an adjusted odds ratio of 0.89 (95% confidence interval 0.84-0.94) at the age of 80.

Conclusion

Despite having smaller vessels than men, women were treated less often with DES. These findings apply to women above the age of 75 years. These findings support previous reports, that elderly women with coronary artery disease are treated differently to men.

Peer Review reports

Background

Cardiovascular disease remains the leading cause of death in Europe and North-America [1]. Evidence-based treatment of cardiovascular disease, according to European and American guidelines, should not differ between women and men, wether for stable coronary artery disease, acute coronary syndromes or for revascularisation procedures. Nevertheless, gender differences in the treatment of cardiovascular disease is well recognized, with women receiving less evidence-based care. In acute coronary syndromes, women still receive beta-blockers, ace-inhibitors and statins less frequently than men [2]. Furthermore, invasive diagnosis and treatment (by heart catheterisation and PCI), the most effective treatment especially in high risk NSTEMI and STEMI, is withheld from women frequently [3]. One postulated reason for this is the higher age of women at the time of diagnosis and treatment. Another reason is that women are less frequently investigated for coronary disease since the condition is still regarded as a “male” disease. Furthermore, the presenting symptoms of women with coronary artery disease are frequently overlooked, due to their different and so-called “atypical” presentation [4].

Due to their on average smaller height and size, women do have smaller coronary arteries, which may be one reason for inferior results following revascularisation procedures, either Percutaneous Coronary Intervention PCI [5] or Coronary Artery Bypass Grafting [6]. Given the substantially higher risk of restenosis in smaller vessels [7, 8] the attraction of DES in reducing target lesion revascularisation [9–13], should mean a higher usage of DES in women is warranted.

To evaluate possible gender differences, we analysed the ALKK-PCI registry for gender differences and other variables in the usage of Drug Eluting Stents (DES) and Bare Metal Stents (BMS).

Materials

Data from 100704 stent implantations performed during 82304 interventions were prospectively collected in the German ALKK-registry (Arbeitsgemeinschaft Leitende Kardiologische Krankenhausärzte) from 1st quarter 2005 to 4th quarter 2009. In the present analysis, data from 28 centres in Germany which participated continuously during the whole period were included. The project started in 1992 as a prospective registry for quality control in PTCA. The registry collects data about indication, technical aspects, medication and hospital outcome including in-hospital complications. Since 2002, the registry is based on an obligatory quality control program that has been introduced in Germany, which requires and checks consecutive enrolment and the completeness of a core dataset. The data were collected electronically and transferred in anonymised form to the Institut für Herzinfarktforschung for editing and statistical analysis. The study is purely observational and was approved by the ethics committee of the Landesaerztekammer Rheinland-Pfalz. None of the authors has competing interests concerning scope and results of the analysis.

All consecutive documented stent implantations for ST-elevation myocardial infarction (STEMI), Non-ST-elevation-Acute Coronary Syndrome (NSTE-ACS), or stable Coronary Artery Disease (CAD) were included in the present analysis.

Methods

Statistical analyses

Patients’ baseline and angiographic characteristics for both sexes are presented as percentages and absolute values with regard to categorical variables and compared by Pearson chi-squared test and odds ratios with 95%-confidence intervals. The distribution of continuous variables is characterised by median and quartiles and compared between genders by Wilcoxon rank-sum test. The stent diameter and the number of stents per procedure is summarized by mean and standard deviation. These descriptive statistics are based on the available cases. As patients admitted multiple times cannot be identified in the data base, we considered different interventions to be independent.

The proportion of DES compared to all implanted stents is shown for men and women in categories of relevant factors. The 95%-intervals of odds ratios adjusted standard errors were calculated using the Taylor linearization technique to allow for clustering. The use of DES in categories of age and indication for PCI is visualised in bar charts and tested for interaction by the Breslow-Day test.

In order to adjust the effect of gender on the choice of a drug eluting stent for other determinants, the variables whose distributions differed significantly between men and women on the one hand and DES and BMS on the other hand as well as the significant interaction of age and gender were included in a multivariable logistic model. As multiple stents implanted during the same session strongly tended to be of the same type, generalized estimating equations assuming an exchangeable working correlation structure were applied and robust standard errors calculated for the odds ratios. For explanatory variables with missing information of more than 1%, conditional means, calculated by a regression on age, gender and indication for PCI, were used.

All p-values are the results of two-tailed tests. P-values ≤ 0.05 were considered significant. The statistical calculations have been performed using the SAS system release 9.3 on a personal computer (SAS Institute, Cary, NC, USA).

Results

Patient characteristics

Women were significantly older than men (71.9 vs. 66.7 years) and were more likely to suffer from diabetes (26.5% vs 20.2%). In contrast, men more often had previous CABG or PCI (13.0% vs. 8.2% and 34.7% vs. 28.2%), while there was no difference regarding renal failure (Table 1).

Table 1 Patient and procedural chracteristics
Full size table

The presentation with STEMI, NSTEMI or stable CAD as well as cardiogenic shock and with or without signs of heart failure, showed statistically significantly different but numerically similar values between genders. The same holds true for the lesion characteristics, where we found more left anterior descending (LAD) lesions and fewer left circumflex (CX) lesions, stent re-stenosis and complex lesions in women than in men. The centre experience in terms of stent implantations performed per year was comparable for men and women.

Usage of DES from 2005 to 2009

Between 1st quarter 2005 and 4th quarter 2009, the use of DES increased from 16.0% to 43.9%. After a rapid increase from 2005 to early 2006, the implantation rate reached a plateau and decreased thereafter. Beginning with the 1st quarter 2008, the rate of DES Implantation steadily increased until the end of the observation period. For all quarters of a year that have been analysed, women received lower rates of DES (p < 0.001; Fig. 1).

Fig. 1
figure 1

Percentage of DES use in women and men between 1st quarter 2005 (Q1) until 4th quarter 2009 (Q4)

Full size image

Stent diameter

Compared to men, women received stents with lower diameters, with a mean ± standard deviation of 2.94 ± 0.48 mm vs. 3.04 ± 0.53 mm (p < 0.0001) than in men (median 3.0 (quartiles 2.5-3.0) mm vs. 3.0 (2.7-3.5) mm, Fig. 2a). This difference between women and men was the same for BMS (2.96 ± 0.48 vs. 3.07 ± 0.53 mm respectively (p < 0.0001) (Fig. 2b), and DES, with a mean of 2.89 ± 0.48 vs. 2.97 ± 0.51 mm (p < 0.0001) (Fig. 2c).

Fig. 2
figure 2

Box plots of stent diameter. Overall stent diameter (a) was larger in men than in women, as was stent diameter of BMS (b) and DES(c). Furthermore, overall DES diameter was smaller compared to BMS

Full size image

Relative use of DES in women and men according to indication

All indications for stent implantation show a lower DES use in women compared to men. While for stable coronary artery disease and NSTEMI there was significant difference of 4.0 and 2.5% (p < 0.001) respectively, the use of DES in STEMI showed a trend (p < 0.086) with an absolute 1% lower use of DES in women (Fig. 3). However, no significant interaction was detected (p = 0.11).

Fig. 3
figure 3

Relative amount of DES implantation rates in women and men for different age groups

Full size image

Age dependent rate of DES use in women and men

For the women under age 50 years and between 50 and 60 years, there was a trend (p = 0.056 and p = 0.066) to a higher use of DES in women compared to men, with a difference of 2.7 and 2.6%, respectively. In the age group between 60 and 70 years, there is a non significant difference of 0.7%, while women between 70 and 80 years and over 80 years receive fewer DES compared to men, 2.8% (p < 0.001) and 4.6% (p < 0.001) respectively. The age group over 70 years comprises over 42% of the stent implantations that were analysed (Fig. 4). The interaction was highly significant (p < 0.0001).

Fig. 4
figure 4

Percentage of DES use in stable CAD, NSTEMI- and STEMI-ACS

Full size image

Variables correlating with use of DES

In both genders, heart failure and renal disease are related to the predominant use of BMS instead of DES (Table 2), while diabetes and previous PCI or CABG were associated with a higher use of DES. Concerning the treated lesions, in-stent restenosis and complex anatomy as well as left main stem or LAD locations correlated with greater DES use.

Table 2 Use of DES in women and men
Full size table

In the multivariable model, diabetes was a strong predictor of DES use (OR 1.39, p < 0.001), while STEMI (OR 0.34, p < 0.001), cardiogenic shock (OR 0.56, p < 0.001), NSTEMI-ACS (OR 0.61, p < 0.001), stent diameter (OR 0.67 for every mm increase in stent diameter, p < 0.001) and age (OR 0.80 for every 10 years increase in age) and female gender (above the age of 75) were all associated with a lower usage of DES. As a significant interaction between age and gender has been detected (p < 0.0001), the effect estimates of age are reported separately for men and women, and those of female gender for distinct age values (Table 3). When we fitted the regression model separately in the subgroups of stable CAD, NSTE-ACS and STEMI, the adjusted effect of female gender on the use of DES was strongest in patients with stable CAD (OR 0.88 (0.82-0.94) at age 80 years), weaker in NSTE-ACS (OR 0.90 (0.80-0.99)) and insignificant in STEMI (OR 1.00 (0.85-1.18)).

Table 3 ALKK PCI-registry 2005-2009: Adjusted effects for the usage of DES in all stent implantations (n = 29374/97491)
Full size table

Adjuvant medical therapy, major adverse cardiac and cerebrovascular event (MACCE) and access site complications

Medical therapy including platelet inhibition and anticoagulation in patients aged 70 years and older did not show a clinically relevant difference between women and men. However, in-hospital mortality and MACCE were significantly higher in women. Most notably, the difference was driven by a significant difference in stable CAD (Table 4). Non-MACCE related access site complications, predominantly bleeding, were more common in women than in men; the difference was significant for all indications (Table 4).

Table 4 Adjuvant medical therapy, MACCE and access site complications in women and men ≥ 70 years
Full size table

Discussion

The main finding of our analysis is a lower rate of DES in elderly women, which is not in accordance with contemporary guidelines on revascularisation [14].

Gender, vessel size and DES use

Correlated with a smaller body surface area [15], women have smaller diameter coronary arteries than men, which explains the inferior results in revascularisation procedures, either PCI [5] or CABG [6]. In the ALKK (Arbeitsgemeinschaft Leitende Kardiologische Krankenhausärzte)-PCI registry we found that stents used in women were smaller than those used in men, either for BMS and DES (Fig. 2a, b, c). These data indirectly confirm, that women have smaller epicardial vessels. For both genders, DES were more frequently used in smaller vessels, which reflects the fact that our data were derived from 2005 to 2009, before large data on the use of DES in larger vessels were available [16, 17]. The tendency to use DES in smaller vessels suggests women may receive a predominance of DES compared to men. However, univariate analysis showed that women received a lower percentage of DES compared to men between 2005 and 2009 (Fig. 1). Further analysis in a multivariable logistic model revealed that the lower likelihood for women to receive a DES is observed only in women above the age of 75 year.

The finding of less frequent DES use in women were also evident irrespective of different indications for PCI, like stable angina, NSTEMI and STEMI. However, while the difference in the two former were statistically significant, there was only a trend towards a lower usage of DES in the latter (Fig. 3). The higher frequency of DES implantation in stable disease compared to ACS reflects data progression suggesting superiority of DES even in STEMI-ACS [18]. This benefit of DES use in ACS is confined to reduced repeat target revascularisation, rather than lower mortality [19].

Explanations for the lower use of DES in elderly women

The underuse of DES is an unexpected finding with different possible explanations:

First, the lower rates of DES in older women could be a chance finding. However, the large number of stent implantations and the high significance (p < 0,001) render this explanation unlikely. Furthermore, the adjusted effects show a higher usage of DES in diabetes, whereas ACS and cardiogenic shock were correlated with a lesser use of DES (Table 1). These results are all quite expected and confirm the plausibility of the database.

Another explanation could be an unknown confounder accounting for the findings. Concerns exist regarding DES (and hence dual antiplatelet therapy) use where there is the need for oral anticoagulation, (such as after implantation of a mechanical heart valve or as a result of repeated thrombo-embolic disease). A commonly encountered scenario is dual antiplatelet therapy (DAPT) in addition to oral anticoagulation for patients with atrial fibrillation. The burden of atrial fibrillation is unlikely to explain the disparity in DES use in women over 75 compared to men over 75 however because although information about long term anticoagulation or about atrial fibrillation are not available in our database, the Framingham heart study [20] suggests atrial fibrillation is 1.5 times more common in men over 75 compared to women over 75 so this in itself is unlikely to explain lower DES use in women of this age. Operators may attribute a higher risk of bleeding to elderly women, which is based on objective data on higher peri-procedural bleeding complications [21] and a higher prevalence of anemia [22], that are also predictors of long term mortality [23], as well as a subjective perception of frailty in elderly women.

Therefore, even if peri-procedural bleeding complications do not differ depending on the stent used, the awareness of a higher liability for bleeding could have encouraged interventionalists to rather use BMS instead of DES, whenever there is a suspected risk of bleeding complications, which is typically encountered in elderly women. Interestingly, the tendency to use BMS instead of DES is confined to the type of stent, since anti-platelet therapy and anticoagulation do not differ (Table 4). Especially the use of GPIIb/IIIa inhibitors, which are known for a higher rate of periprocedural bleeding complications [24] (Table 4), was similar in both genders.

Actually, our study (Table 4) confirms a substantially higher periprocedural risk of access site complication, bleeding, MACCE and death in women [15, 25, 26]. Given the higher probability of target lesion revascularisations for in stent restenoses with

BMS [27], elderly women are likely exposed to a higher overall risk due to repeat revascularisation procedures.

Paradoxically, the intention to prevent bleeding complications in women by the use of BMS instead of DES, could actually increase morbidity and mortality.

There could be doubts regarding the efficacy of DES in women, (as women are thought to have less complex coronary lesions [28] which could be treated equally with BMS or DES), particularly as DES are more expensive than BMS. Indeed, Our data shows, a lower percentage of complex lesions and in-stent restenosis in women comared to men. While there is a lack of improvement for mortality and MI, adequately powered RCTs impressively demonstrated a reduction of target vessel revascularisation with DES compared to BMS, which were similar for both sexes [28], even in the elderly [29]. These results were confirmed by registry data on the use of DES, that show that these findings proved to be valid in daily practice [30].

The data from the PCI registry show, that women receive lower percentage of DES compared to men; this difference is significant only for the age groups over 70 years (Fig. 4). However, the age group between 70 and 80 years is the largest in the registry and overall, people older than 70 years account for more than 40% of the sample. Given the high number of PCIs analysed, these data are considered to be clinically relevant, showing that women do not receive best available treatment for coronary artery disease.

Duration of dual anti-platelet therapy

The duration of DAPT was not included in our database, however, according to guidelines, patients with STEMI and NSTEMI received DAPT for 12 month, independent of stent type, while patients with stable CAD received DAPT for one or six month for BMS and DES, respectively. Actually, we found the biggest difference in stent usage in the group with stable angina. Given there are more bleedings, this could explain the tendency to prefer BMS in elderly woman in the era of 1st generation DES.

However, latest data for 2nd generation DES show good results for short DAPT, favouring a DAPT for only three month [31] in patients with concerns of bleeding. This shortening of DAPT should further reduce the difference in DES use between men and women.

Limitations

Our large sample, which is representative for current PCI-procedures in Germany provides data on the use of DES and BMS in women and men in different revascularisation settings. However, our study has some limitations.

First, whilst we adjusted for baseline differences, we cannot fully eliminate them. As a result, it is possible that unmeasured confounders (especially atrial fibrillation and oral anticoagulation therapy requirement) exist and may have contributed to the differences observed. Second, the analysis that was performed is retrospective and is, therefore, dependent on the data already collected.

Conclusion

The ALKK-PCI database shows a distinctly lower use of DES in elderly women. This difference is not supported by guidelines or recent published trials. As undertreatment cannot be studied by randomised controlled trials, other available databases on PCI should be analysed for gender differences in DES implantation.

More effort should be made to uniformly implement of current revascularisation guidelines across groups, thereby eliminating gender differences in care.

Abbreviations

ACS:

Acute coronary syndrome

ALKK:

Arbeitsgemeinschaft Leitende Kardiologische Krankenhausärzte

BMS:

Bare metall stent

CABG:

Coronary artery bypass grafting

CAD:

Coronary artery disease

CX:

Left circumflex artery

DAPT:

Dual antiplatelet therapy

DES:

Drug eluting stent

HF:

Heart failure

ISR:

In-stent restenosis

LAD:

Left anterior descending artery

MACCE:

Major adverse cardiac and cerebrovascular event

NSTEMI:

Non ST-elevation myocardial Infarction

OR:

Odds ratio

PCI:

Percutaneous coronary intervention

RCA:

Right coronary artery

RCT:

Randomized controlled trial

STEMI:

ST-elevation myocardial infarction

References

  1. Stramba-Badiale M, Fox KM, Priori SG, et al. Cardiovascular diseases in women: a statement from the policy conference of the European Society of Cardiology. Eur Heart J. 2006;27:994–1005.

    Article  PubMed  Google Scholar 

  2. Bugiardini R, Yan AT, Yan RT, et al. Factors influencing underutilization of evidence-based therapies in women. Eur Heart J. 2011;32:1337–44.

    Article  CAS  PubMed  Google Scholar 

  3. Blomkalns AL, Chen AY, Hochman JS, et al. Gender disparities in the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes: large-scale observations from the CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the American College of Cardiology/American Heart Association Guidelines) National Quality Improvement Initiative. J Am Coll Cardiol. 2005;45:832–7.

    Article  PubMed  Google Scholar 

  4. Douglas PS, Ginsburg GS. The evaluation of chest pain in women. N Engl J Med. 1996;334:1311–5.

    Article  CAS  PubMed  Google Scholar 

  5. Kim C, Redberg RF, Pavlic T, et al. A systematic review of gender differences in mortality after coronary artery bypass graft surgery and percutaneous coronary interventions. Clin Cardiol. 2007;30:491–5.

    Article  PubMed  Google Scholar 

  6. Lehmkuhl E, Kendel F, Gelbrich G, et al. Gender-specific predictors of early mortality after coronary artery bypass graft surgery. Clin Res Cardiol. 2012;101:745–51.

    Article  CAS  PubMed  Google Scholar 

  7. Elezi S, Kastrati A, Neumann FJ, et al. Vessel size and long-term outcome after coronary stent placement. Circulation. 1998;98:1875–80.

    Article  CAS  PubMed  Google Scholar 

  8. Kastrati A, Schomig A, Elezi S, et al. Predictive factors of restenosis after coronary stent placement. J Am Coll Cardiol. 1997;30:1428–36.

    Article  CAS  PubMed  Google Scholar 

  9. Puymirat E, Mangiacapra F, Peace A, et al. Long-term clinical outcome in patients with small vessel disease treated with drug-eluting versus bare-metal stenting. Am Heart J. 2011;162:907–13.

    Article  CAS  PubMed  Google Scholar 

  10. Ardissino D, Cavallini C, Bramucci E, et al. Sirolimus-eluting vs uncoated stents for prevention of restenosis in small coronary arteries: a randomized trial. JAMA. 2004;292:2727–34.

    Article  CAS  PubMed  Google Scholar 

  11. Schampaert E, Cohen EA, Schluter M, et al. The Canadian study of the sirolimus-eluting stent in the treatment of patients with long de novo lesions in small native coronary arteries (C-SIRIUS). J Am Coll Cardiol. 2004;43:1110–5.

    Article  CAS  PubMed  Google Scholar 

  12. Bangalore S, Kumar S, Fusaro M, et al. Short- and long-term outcomes with drug-eluting and bare-metal coronary stents: a mixed-treatment comparison analysis of 117 762 patient-years of follow-up from randomized trials. Circulation. 2012;125:2873–91.

    Article  CAS  PubMed  Google Scholar 

  13. Kastrati A, Mehilli J, Pache J, et al. Analysis of 14 trials comparing sirolimus-eluting stents with bare-metal stents. N Engl J Med. 2007;356:1030–9.

    Article  CAS  PubMed  Google Scholar 

  14. Wijns W, Kolh P, Danchin N, et al. Guidelines on myocardial revascularization. Eur Heart J. 2010;31:2501–55.

    Article  PubMed  Google Scholar 

  15. Thompson CA, Kaplan AV, Friedman BJ, et al. Gender-based differences of percutaneous coronary intervention in the drug-eluting stent era. Catheter Cardiovasc Interv. 2006;67:25–31.

    Article  PubMed  Google Scholar 

  16. Kaiser C, Galatius S, Erne P, et al. Drug-eluting versus bare-metal stents in large coronary arteries. N Engl J Med. 2010;363:2310–9.

    Article  CAS  PubMed  Google Scholar 

  17. Cortese B, Bertoletti A, De Matteis S, et al. Drug-eluting stents perform better than bare metal stents in small coronary vessels: A meta-analysis of randomised and observational clinical studies with mid-term follow up. Int J Cardiol. 2012;161(2):73–82.

    Article  PubMed  Google Scholar 

  18. Spaulding C, Henry P, Teiger E, et al. Sirolimus-Eluting versus Uncoated Stents in Acute Myocardial Infarction. N Engl J Med. 2006;355:1093–104.

    Article  CAS  PubMed  Google Scholar 

  19. Kastrati A, Dibra A, Spaulding C, et al. Meta-analysis of randomized trials on drug-eluting stents vs. bare-metal stents in patients with acute myocardial infarction. Eur Heart J. 2007;28:2706–13.

    Article  PubMed  Google Scholar 

  20. Benjamin EJ, Levy D, Vaziri SM, et al. Independent risk factors for atrial fibrillation in a population-based cohort. The Framingham Heart Study. JAMA. 1994;271:840–4.

    Article  CAS  PubMed  Google Scholar 

  21. Ahmed B, Piper WD, Malenka D, et al. Significantly improved vascular complications among women undergoing percutaneous coronary intervention: a report from the Northern New England Percutaneous Coronary Intervention Registry. Circ Cardiovasc Interv. 2009;2:423–9.

    Article  PubMed  Google Scholar 

  22. Nikolsky E, Mehran R, Aymong ED, et al. Impact of anemia on outcomes of patients undergoing percutaneous coronary interventions. Am J Cardiol. 2004;94:1023–7.

    Article  PubMed  Google Scholar 

  23. Rao SV, Dai D, Subherwal S, et al. Association between periprocedural bleeding and long-term outcomes following percutaneous coronary intervention in older patients. JACC Cardiovasc Interv. 2012;5:958–65.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Labinaz M, Ho C, Banerjee S, et al. Meta-analysis of clinical efficacy and bleeding risk with intravenous glycoprotein IIb/IIIa antagonists for percutaneous coronary intervention. Can J Cardiol. 2007;23:963–70.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Duvernoy CS, Smith DE, Manohar P, et al. Gender differences in adverse outcomes after contemporary percutaneous coronary intervention: an analysis from the Blue Cross Blue Shield of Michigan Cardiovascular Consortium (BMC2) percutaneous coronary intervention registry. Am Heart J. 2010;159:677–83. e1.

    Article  PubMed  Google Scholar 

  26. Anderson ML, Peterson ED, Brennan JM, et al. Short- and long-term outcomes of coronary stenting in women versus men: results from the National Cardiovascular Data Registry Centers for Medicare & Medicaid services cohort. Circulation. 2012;126:2190–9.

    Article  PubMed  Google Scholar 

  27. Stefanini GG, Baber U, Windecker S, et al. Safety and efficacy of drug-eluting stents in women: a patient-level pooled analysis of randomised trials. Lancet. 2013;382:1879–88.

    Article  CAS  PubMed  Google Scholar 

  28. Stefanini GG, Kalesan B, Pilgrim T, et al. Impact of sex on clinical and angiographic outcomes among patients undergoing revascularization with drug-eluting stents. JACC Cardiovasc Interv. 2012;5:301–10.

    Article  PubMed  Google Scholar 

  29. de Belder A, Maria de la Torre Hernandez J, Lopez-Palop R, et al. A Prospective Randomized Trial Of Everolimus-Eluting Stents Versus Bare Metal Stents In Octogenarians: Xience Or Vision Stents For The Management Of Angina In The Elderly - The Xima Trial. J Am Coll Cardiol. 2014;63(14):1371–5.

    Article  PubMed  Google Scholar 

  30. Onuma Y, Kukreja N, Daemen J, et al. Impact of sex on 3-year outcome after percutaneous coronary intervention using bare-metal and drug-eluting stents in previously untreated coronary artery disease: insights from the RESEARCH (Rapamycin-Eluting Stent Evaluated at Rotterdam Cardiology Hospital) and T-SEARCH (Taxus-Stent Evaluated at Rotterdam Cardiology Hospital) Registries. JACC Cardiovasc Interv. 2009;2:603–10.

    Article  PubMed  Google Scholar 

  31. Palmerini T, Sangiorgi D, Valgimigli M, Biondi-Zoccai G, Feres F, Abizaid A, Costa RA, Hong MK, Kim BK, Jang Y, Kim HS, Park KW, Mariani A, Della Riva D, Genereux P, Leon MB, Bhatt DL, Bendetto U, Rapezzi C, Stone GW. “Short- Versus Long-Term Dual Antiplatelet Therapy After Drug-Eluting Stent Implantation: An Individual Patient Data Pairwise and Network Meta-Analysis”. J Am Coll Cardiol. 2015;65:1092–102.

Download references

Acknowledgements

We would like to thank Dr. Justin M. Carter, Consultant Cardiologist, North Tees and Hartlepool NHS Trust, helping us with english wording an writing.

Funding

The “Institut für Herzinfarkforschung“, a national foundation, provided data and statistical analysis. Further funding does not exist.

Availability of data and materials

All data which are presented in the manuscript are taken from the PCI-registry of the “Institut für Herzinfarkforschung“. On request, these analysis are avaible. Please refer to martin.russ@posteo.de.

Authors’ contribution

Made substantial contributions to data analysis MR, CW, MH, UZ and MW made substantial contibutions to study design and data analysis and interpretation. MR, MH, ZU, SK, RZ, BZ, HT and VS drafted the manuskript or revised it critically for important intellectual content. All authors have given final approval of the version to be published.

Competing interests

None of the authors has competing interests concerning scope and results of the analysis.

Consent for publication

Not applicable.

Ethics approval and consent to participate

The study is purely observational and was approved by the ethics committee of the Landesaerztekammer Rheinland-Pfalz. Consent to participate was obtained from every patient after PCI.

Author information

Authors and Affiliations

  1. Internistische Praxis am Maxplatz, Maxplatz 12, 83278, Traunstein, Germany

    Martin A. Russ

  2. Amper-Klinikum, Dachau, Krankenhausstrasse 15, 85221, Dachau, Germany

    Martin A. Russ, Christian Wackerl & Michael A. Weber

  3. Institut für Herzinfarktforschung, Bremserstr, 79, 67063, Ludwigshafen, Germany

    Uwe Zeymer & Matthias Hochadel

  4. Medizinische Klinik B - Abteilung für Kardiologie, Bremserstr. 79, 67063, Ludwigshafen, Germany

    Uwe Zeymer & Ralf Zahn

  5. Herz- und Gefäß-Klinik GmbH Bad Neustadt, Salzburger Leite1, 97616, Bad Neustadt a.d. Saale, Germany

    Sebastian Kerber

  6. Krankenhaus Landshut-Achdorf, Medizinische Klinik I, Achdorfer Weg 3, 84036, Landshut, Germany

    Bernhard Zrenner

  7. Sana-Klinikum Hameln-Pyrmont, Saint-Maur-Platz 1, 31785, Hameln, Germany

    Hubert Topp

  8. Klinikum Fulda, Medizinische Klinik I, Pacelliallee 4, 36043, Fulda, Germany

    Volker Schächinger

Authors
  1. Martin A. Russ
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Christian Wackerl
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Uwe Zeymer
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Matthias Hochadel
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Sebastian Kerber
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Ralf Zahn
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Bernhard Zrenner
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Hubert Topp
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Volker Schächinger
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Michael A. Weber
    View author publications

    You can also search for this author in PubMed Google Scholar

Consortia

for the ALKK-Study Group

Corresponding author

Correspondence to Martin A. Russ.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Russ, M.A., Wackerl, C., Zeymer, U. et al. Gender based differences in drug eluting stent implantation - data from the German ALKK registry suggest underuse of DES in elderly women. BMC Cardiovasc Disord 17, 68 (2017). https://doi.org/10.1186/s12872-017-0500-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1186/s12872-017-0500-y

Keywords

BMC Cardiovascular Disorders

ISSN: 1471-2261

Contact us