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Common ALDH2 genetic variants predict development of hypertension in the SAPPHIRe prospective cohort: Gene-environmental interaction with alcohol consumption

  • Yi-Cheng Chang1, 2,
  • Yen-Feng Chiu3,
  • I-Te Lee4,
  • Low-Tone Ho5, 6, 7,
  • Yi-Jen Hung8,
  • Chao A Hsiung3,
  • Thomas Quertermous9,
  • Timothy Donlon10,
  • Wei-Jei Lee11,
  • Po-Chu Lee12,
  • Che-Hong Chen13,
  • Daria Mochly-Rosen13 and
  • Lee-Ming Chuang1, 14Email author
Contributed equally
BMC Cardiovascular Disorders201212:58

DOI: 10.1186/1471-2261-12-58

Received: 17 April 2012

Accepted: 11 July 2012

Published: 29 July 2012

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting

Original Submission
17 Apr 2012 Submitted Original manuscript
Resubmission - Version 2
Submitted Manuscript version 2
8 May 2012 Reviewed Reviewer Report - David Conen
14 May 2012 Reviewed Reviewer Report - Halina Cichoz-Lach
5 Jun 2012 Author responded Author comments - Yi-Cheng Chang
Resubmission - Version 3
5 Jun 2012 Submitted Manuscript version 3
3 Jul 2012 Reviewed Reviewer Report - David Conen
Resubmission - Version 4
Submitted Manuscript version 4
11 Jul 2012 Editorially accepted
29 Jul 2012 Article published 10.1186/1471-2261-12-58

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

Department of Internal Medicine, National Taiwan University Hospital
Genomics Research Center, Academia Sinica
Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes
Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital
Department of Medical Research and Education, Taipei Veterans General Hospital
Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital
Faculty of Medicine, School of Medicine, National Yang-Ming University
Division of Endocrinology & Metabolism, Tri-Service General Hospital, National Defense Medical Center
Division of Cardiovascular Medicine, Falk Cardiovascular Research Building, Stanford University School of Medicine
Kuakini Medical Center
Department of Surgery, Min-Sheng Hospital
Department of General Surgery, National Taiwan University Hospital
Department of Chemical and Systems Biology, School of Medicine Stanford University
Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine